Spray-dried chitosan microspheres with lecithin nanocores as cyclosporin A delivery system (CROSBI ID 545321)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Davosir Klarić, Željka ; Hafner, Anita ; Tomić, Siniša ; Zubčić, Snježana ; Filipović-Grčić, Jelena
engleski
Spray-dried chitosan microspheres with lecithin nanocores as cyclosporin A delivery system
Cyclosporin is a highly lipophilic neutral cyclic peptide consisting of 11 amino acids. Its low water solubility present a serious problem causing undesirable biopharmaceutical properties, such as erratic bioavailability from oral and topical routes (1). To overcome this problem bioadhesive drug delivery system like chitosan microspheres could be used (2). Chitosan, a polycationic biopolymer is well known for its several favorable biological properties such as biodegradability, nontoxicity and biocompatibility (2). In this study spray-drying method was used for preparing chitosan microspheres with lecithin nanocores as delivery system for cyclosporin A (CyA). The swelling properties of the microspheres and in vitro CyA release were investigated. A new method for the preparation of spray-dried CyA-loaded hydrophilic microspheres was developed. Incorporation of lecithin nanocores into hydrophylic chitosan matrix resulted in improved CyA entrapment, swelling ability and control over CyA release.
Spray-driying; Chitosan; Microspheres; Lecithin; Cyclosporin A
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Podaci o prilogu
115-116.
2008.
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objavljeno
Podaci o matičnoj publikaciji
Farmacevtski vestnik
Mrhar, Aleš ; Baumgartner, Saša
Ljubljana: Slovenian Pharmaceutical Society
0014-8229
Podaci o skupu
7th Central Europen Symposium on Pharmaceutical Technology and Biodekivery Systems
poster
18.09.2008-20.09.2008
Ljubljana, Slovenija