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Pregled bibliografske jedinice broj: 385151

Časopis

Autori: Romeo, Elena; Živković, Ilija; Costa Erminio
Naslov: Mitochondrial Diazepam-Binding Inhibitor Receptor Complex Agonists Antagonize Dizocilpine Amnesia: Putative Role for Allopregnanolone
Izvornik: Journal of Pharmacology and Experimental Therapeutics (0022-3565) 270 (1994), 1; 89-96
Vrsta rada: članak
Ključne riječi: Mitocondrial diazepam-binding inhibitor; Dizocilpine Amenzia; Allopregnanolone; THDOC
Sažetak:
In rats trained to retain a passive avoidance response or to retrieve a learned task in the radial and water maze tests, a pretreatment with 2-hexyl-3-indoleacetamide (FGIN-1-27) (IC50 57 mu mol/kg p.o.) or 4'chlorodiazepam (4'CD) (15 mu mol/kg i.p.), two steroidogenic ligands at the mitochondria diazepam-binding inhibitor receptor complex (MDRC), antagonized the performance deficit elicited by dizocilpine (0.3 mu mol/kg i.p.), a noncompetitive N-methyl-D-aspariate (NMDA) receptor antagonist. The 1-(2-chlorophenyl)-N-methyl-N-(-1-methyl-propyl)-3-isoquinoline carboxamide (PK-11195), an antagonist at MDRC in vivo, failed to modify the disruptive effect of dizocilpine in the passive avoidance response but reversed the FGIN-1-27- or 4'CD-induced antagonism of dizocilpine behavioral actions. Pretreatment with pregnenolone sulfate (48 mu mol/kg i.p.), 3 alpha, 21-dihydroxy-5 alpha-pregnan-20-one (THDOC) (15 mu mol/kg i.v.) and 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) (15 mu mol/kg i.v.) also reduced the passive avoidance retention deficit elicited by dizocilpine. The (17-beta)-17-[[bis(1-methylethyl)amino[carbonyl]androstane-3, 5-diene-3-carboxylic acid (SKF-105111), a 5 alpha-reductase inhibitor, blocked the antagonism of dizocilpine behavioral actions by pregnenolone sulfate or by FGIN-1-27 but not those caused by THDOC or allopregnanolone either in normal or adrenalectomized-castrated rats. Thus, it is inferred that the amnesic effect of dizocilpine is counteracted by FGIN-1-27, 4'CD and pregnenolone sulfate because of their ability to increase brain accumulation of allopregnanolone.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Psihologija
URL cjelovitog teksta:
Google Scholar: Mitochondrial Diazepam-Binding Inhibitor Receptor Complex Agonists Antagonize Dizocilpine Amnesia: Putative Role for Allopregnanolone
Upisao u CROSBI: izivkovic@kbf.hr (izivkovic@kbf.hr), 12. Ožu. 2009. u 17:44 sati
Napomene:
Ovaj rad se bavi pitanjem amnezije i pokušajem da se kemijskim tvarima utječe na kompleksne receptore MDRC koji se lako vežu na poznati diazepam. Receptorski antagonist NMDA (N-methyl-D-aspartat) povećao je učinak amnezije skupa sa dizolcipinom. Primjenom tvari FGIN-1-27 u znatnoj mjeri je otklonjen deficit memorije kod životinja, no još uvijek nedovoljno da bi bio obećavajući u učinkovitom tretmanu amnezije



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