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Pregled bibliografske jedinice broj: 386055

Časopis

Autori: Novak, Predrag; Tepeš, Predrag; Ilijaš, Marina; Fistrić, Ines; Bratoš, Igor; Avdagić, Amir; Hameršak, Zdenko; Gabelica Marković, Vesna; Dumić, Miljenko
Naslov: Rapid LC-NMR and LC-MS characterization of an unknown component in a novel antifungal drug Icofungipen
( Rapid LC-NMR and LC-MS characterization of an unknown component in a novel antifungal drug Icofungipen )
Izvornik: Journal of Pharmaceutical and Biomedical Analysis (0731-7085) 50 (2009), 1; 68-72
Vrsta rada: članak
Ključne riječi: Icofungipen; impurity; liquid chromatography - nuclear magnetic resonance spectroscopy; liquid chromatography - mass spectrometry
( cofungipen; impurity; liquid chromatography - nuclear magnetic resonance spectroscopy; liquid chromatography - mass spectrometry )
Sažetak:
A successful use of LC-NMR and LC-MS for a rapid identification of the unknown component in a novel antifungal drug Icofungipen has been demonstrated. Complementary information obtained from the two methods made it possible to identify and determine the structure of A1 prior to its isolation and purification. The analysis of the stop-flow LC-NMR (1H and DQFCOSY), LC-MS and LC-MS/MS spectra has shown that A1 is structurally related to Icofungipen. The impurity A1 was later isolated and prepared synthetically and its structure was corroborated by high-resolution NMR spectroscopy. The combined use of LC-NMR and LC-MS methodology as described here can serve as an efficient, fast and reliable tool for determination of the Icofungipen impurities in the following production process.
Projekt / tema: 006-0000000-3216, 119-1191342-1083, 098-0982933-2908
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Broj citata:
Altmetric:
DOI: 10.1016/j.jpba.2009.03.017
URL cjelovitog teksta:
Google Scholar: Rapid LC-NMR and LC-MS characterization of an unknown component in a novel antifungal drug Icofungipen
Upisao u CROSBI: hamer@irb.hr (hamer@irb.hr), 17. Ožu. 2009. u 14:22 sati



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