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Pregled bibliografske jedinice broj: 393174

Časopis

Autori: Ilić, Spomenko; Drmić, Domagoj; Žarković, Kamelija; Kolenc, Danijela; Ćorić, Marijana; Brčić, Luka; Kliček, Robert; Radić, Božo; Sever, Marko; Djuzel, Viktor; Ivica, Mihovil; Boban Blagaić, Alenka; Zoričić, Zoran; Anić, Tomislav; Zoričić, Ivan; Džidić, Senka; Seiwerth, Sven; Sikirić, Predrag
Naslov: Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats
Izvornik: European journal of pharmacology (0014-2999) 667 (2011), 1/3; 322-329
Vrsta rada: članak
Ključne riječi: paracetamol- hepatic encephalopathy – convulsions -pentadecapeptide BPC 157 – rats
Sažetak:
We challenged rats with chronic ibuprofen application (0.4g/kg intraperitoneally once daily for 4 weeks) and the stable gastric pentadecapeptide BPC 157 therapy. We evidenced a deleterious circuit not reported in ibuprofen-rats as yet: hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values, with prolonged sedation/unconsciousness and weight loss. In particular, ibuprofen toxicity exhibited itself as brain edema and cyanosis, particularly in the cerebellum, more so in white than in gray mater, damaged (balonized) red neurons, without any inflammatory reaction, particularly in the cerebral cortex and cerebellar nuclei, less in the hippocampus, dentate nucleus and Purkinje cells. BPC 157 (GEPPPGKPADDAGLV, MW 1419, 10µ ; g, 10ng/kg) was fully effective given as an antidote after ibuprofen: (i) intraperitoneally, immediately after ibuprofen or (ii) in drinking water (0.16 µ ; g, 0.16 ng/ml) until the end of the 4 week-experiment. Thus, apart from its role as an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL14736) and various wound treatment, with no toxicity reported and which already showed various hepatoprotective effects, either BPC 157 regimen counteracted
Projekt / tema: 108-1083570-3635, 108-1080321-0389, 108-1083570-3636, 098-0982464-2519, 108-0000000-0028, 108-1083570-3634, 108-0532264-0048, 108-1083570-3643
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://ac.els-cdn.com/S0014299911006212/1-s2.0-S0014299911006212-main.pdf?_tid=952377d4431e7c54aef9dac8b8dd2b56&acdnat=1345806004_50728879698fa8620b02776de4ce8b83
http://www.sciencedirect.com/science/article/pii/S0014299911006212
Broj citata:
Altmetric:
DOI: 10.1016/j.ejphar.2011.05.038
URL cjelovitog teksta:
Google Scholar: Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats
Upisao u CROSBI: dzidic@irb.hr (dzidic@irb.hr), 25. Svi. 2009. u 10:39 sati



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