engleski

Antioxidants, trace elements and metabolic syndrome in elderly subjects in Croatia

Metabolic syndrome (MetS) parameters were evaluated in relation to the antioxidant and trace element status in mobile elderly population, predominantly from rural areas in Croatia. The study group consisted of 100 subjects, aged 71-88 years: 20 women and 17 men from coastal and 38 women and 25 men from continental region of Croatia. Anthropometric measurements and biochemical analyses of fasting blood samples were performed by standardised methods. MetS was diagnosed according to the International Diabetic Federation (IDF) criteria. The following parameters were determined in all subjects: concentration of glucose, triglycerides, lipoproteins and C-reactive protein (CRP) in plasma, selenium (SSe), zinc (SZn) and copper (SCu) in serum, activity of glutathione peroxidase (GPx) in blood, and superoxide dismutase (SOD) and catalase (CAT) in erythrocytes. Significantly higher GPx was found in 64 subjects with MetS compared to 36 subjects without MetS. Although there was no significant difference in SOD, CAT, SSe, SZn and SCu between the groups regarding the MetS, the lowest SSe and SZn, and the highest CAT and SOD were found in obese subjects with MetS. The results of Spearman correlation of the variables measured in all 100 subjects showed significant positive association between SCu and CRP, SCu and total- and LDL-cholesterol, and between GPx and triglycerides. These findings contribute to a better understanding of the relationships between MetS, oxidative stress and the inflammatory process.

metabolic syndrome; antioxidant status; glucose; C-reactive protein; copper; elderly; selenium; triglycerids; zinc

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