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Pregled bibliografske jedinice broj: 399370

Časopis

Autori: Pham, Bach-Nga; Rudić, Milan; Bouccara, Didier; Sterkers, Olivier; Belmatoug, Nadia; Bebear, Jean-Pierre; Couloigner, Vincent; Fraysse, Bernard; Gentine, Andre; Ionescu, Eugene; Robier, Alain; Sauvage, Jean-Pierre; Truy, Eric; Van Den Abbeele, Thierry; Ferrary, Evelyne
Naslov: Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases
Izvornik: Autoimmunity (0891-6934) 40 (2007), 3; 202-207
Vrsta rada: članak
Ključne riječi: hearing loss; vertigo; Menire's disease; MPZ; myelin P0 protein
Sažetak:
The inner ear can be the target of autoimmune disorders. Recognition of autoimmune inner ear disease is important, as it is one of the very few forms of sensorineural hearing loss (HL) that can be successfully treated by medical therapy. The aim of this study was to evaluate whether the detection of antibodies to myelin protein P0 (MPZ) could be a diagnostic test for inner ear disease of autoimmune cause. This multicentric prospective study included 129 patients: patients with progressive sensorineural HL or with Meniè ; re's disease, together with their control group corresponding to patients with similar symptoms, but of presumably known origin. Detection of antibodies to myelin P0 protein was performed by using western blots. The prevalence of antibodies to myelin P0 protein in patients with rapidly progressive HL was not statistically different from that of the control group corresponding to genetic HL patients (30 versus 28%). In patients with Meniè ; re's disease, the prevalence was lower than that of the control group corresponding to patients with benign paroxysmal positional vertigo (5.4 versus 18.7%). No patient with auto-immune disease had antibodies to myelin P0 protein. The sole presence of antibodies to myelin P0 may not be used as a marker of inner ear disease of autoimmune origin.
Projekt / tema: 098-0982464-2510, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.informaworld.com/smpp/content~db=all?content=10.1080/08916930701248555
http://www.informaworld.com/smpp/ftinterface~content=a777552642~fulltext=713240930
Broj citata:
Altmetric:
DOI: 10.1080/08916930701248555
URL cjelovitog teksta: http://www.informaworld.com/smpp/content~db=all?content=10.1080/08916930701248555
Google Scholar: Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases
Upisao u CROSBI: grce@irb.hr (grce@irb.hr), 2. Lip. 2009. u 18:19 sati



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