Transmethylation, i.e. transfer of methyl group from methionine wia adenosylmethionine to numerous acceptors of very variable function is a crucial function of metabolic reaction between methionine and homocysteine. The fact that transmethylation occurs in all mammalian tissues and cells also reflects its significance. The large list of acceptors of methyl groups transferred by numerous methyltransferases includes important molecules such as DNA, RNA, lipids, proteins and guanidinoacetate. Therefore, the disorder which disturb transmethylation affects numerous tissues and organs.

Kliničke medicinske znanosti