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Pregled bibliografske jedinice broj: 408113

Časopis

Autori: Kliček, Robert; Sever, Marko; Radić, Božo; Drmić, Domagoj; Kocman, Ivica; Zoričić, Ivan; Vukšić, Tihomir; Ivica, Mihovil; Barišić, Ivan; Ilić, Spomenko; Berkopić, Lidija; Vrčić, Hrvoje; Brčić, Luka; Boban Blagaić, Alenka; Ćorić, Marijana; Brčić, Iva; Stančić Rokotov, Dinko; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System
( Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System )
Izvornik: Journal of pharmacological sciences (1347-8613) 108 (2008), 1; 7-17
Vrsta rada: članak
Ključne riječi: stable gastric pentadecapeptide BPC 157; colocutaneous fistula; skin defect; colon defect
( stable gastric pentadecapeptide BPC 157; colocutaneous fistula; skin defect; colon defect )
Sažetak:
We focused on the therapeutic effect of the stable gastric pentadecapeptide BPC 157 and how its action is related to nitric oxide (NO) in persistent colocutaneous fistula in rats (at 5 cm from anus, colon defect of 5 mm, skin defect of 5 mm) ; this peptide has been shown to be safe in clinical trials for inflammatory bowel disease (PL14736) and safe for intestinal anstomosis therapy. BPC 157 (10 μ g/kg, 10 ng/kg) was applied i) in drinking water until the animals were sacrificed at post-operative day 1, 3, 5, 7, 14, 21, and 28 ; or ii) once daily intraperitoneally (first application 30 min following surgery, last 24 h before sacrifice) alone or with NG-nitro-L-arginine methyl ester (L-NAME) (5 mg/kg), L-arginine (200 mg/kg), and their combinations. Sulphasalazine (50 mg/kg) and 6-α -methylprednisolone (1 mg/kg) were given once daily intraperitoneally. BPC 157 accelerated parenterally or perorally the healing of colonic and skin defect, leading to the suitable closure of the fistula, macro/microscopically, biomechanically, and functionally (larger water volume sustained without fistula leaking). L-NAME aggravated the healing failure of colocutaneous fistulas, skin, and colon wounds (L-NAME groups). L-Arginine was effective only with blunted NO generation (L-NAME + L-arginine groups) but not without (L-arginine groups). All of the BPC 157 beneficial effects remained unchanged with blunted NO-generation (L-NAME + BPC 157 groups) and with NO substrate (L-arginine + BPC 157 groups) as well as L-NAME and L-arginine co-administration (L-NAME + L-arginine + BPC 157 groups). Sulphasalazine was only moderately effective, and corticosteroid even had an aggravating effect.
Projekt / tema: 108-1083570-3635, 108-1080321-0389, 108-1083570-3636, 108-0532264-0048, 108-1083570-3643
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.jstage.jst.go.jp/article/jphs/108/1/7/_pdf
http://www.jstage.jst.go.jp/article/jphs/108/1/108_7/_article
Broj citata:
Altmetric:
DOI: 10.1254/jphs.FP0072161
URL cjelovitog teksta:
Google Scholar: Pentadecapeptide BPC 157, in Clinical Trials as a Therapy for Inflammatory Bowel Disease (PL14736), Is Effective in the Healing of Colocutaneous Fistulas in Rats: Role of the Nitric Oxide-System
Upisao u CROSBI: psikiric@mef.hr (psikiric@mef.hr), 8. Lip. 2009. u 17:00 sati



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