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Pregled bibliografske jedinice broj: 408312

Časopis

Autori: Vukšić, Tihomir; Zoričić, Ivan; Brčić, Luka; Sever, Marko; Kliček, Robert; Radić, Božo; Cesarec, Vedran; Berkopić, Lidija; Keller, Neike; Boban Blagaić, Alenka; Kokić, Neven; Jelić, Ivan; Geber, Juraj; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat
( Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat )
Izvornik: Surgery Today (0941-1291) 37 (2007), 9; 768-777
Vrsta rada: članak
Ključne riječi: Pentadecapeptide BPC 157; Ileoileal anastomosis healing; Rat
( Pentadecapeptide BPC 157; Ileoileal anastomosis healing; Rat )
Sažetak:
Purpose Gastric pentadecapeptide BPC 157 (BPC 157), which has been shown to be safe in clinical trials for inflammatory bowel disease (PL-10, PLD-116, PL14736, Pliva, Croatia), may be able to cure intestinal anastomosis dehiscence. This antiulcer peptide shows no toxicity, is limit test negative, and a lethal dose is not achieved. It is stable in human gastric juice. In comparison with other standard treatments it is more effective for ulcers and various wounds, and can be used without a carrier needed for other peptides, both locally and systemically (i.e., perorally, parenterally). We studied the effectiveness of BPC 157 for ileoileal anastomosis healing in rats. Methods We assessed ileoileal anastomosis dehiscence macroscopically, histologically, and biomechanically (volume [ml] infused through a syringe-perfusion pump system (1  ml/10  s), and pressure [mmHg] to leak induction [catheter connected to a chamber and a monitor, at 10  cm proximal to anastomosis]), at 1, 2, 3, 4, 5, 6, 7, and 14 days. BPC 157 (10  µ ; g, 10  ng, 10  pg/kg i.p. (or saline [5  ml/kg]) was first administered after surgery, while it was last given 24  h before either assessment or sacrifice. Results Throughout the experiment, both higher doses of BPC 157 were shown to improve all parameters of anastomotic wound healing. The formation of adhesions remained slight, the blood vessels were filled with blood, and a mild intestinal passage obstruction was only temporarily observed. Anastomosis without leakage induces markedly higher volume and pressure values, with a continuous increase toward healthy values. From day 1, edema was markedly attenuated and the number of granulocytes decreased, while from days 4 or 5 necrosis decreased and granulation tissue, reticulin, and collagen formation substantially increased, thus resulting in increased epithelization. Conclusion This study showed BPC 157 to have a beneficial effect on ileoileal anastomosis healing in the rat.
Projekt / tema: 108-1083570-3635, 108-1083570-3636, 108-1080321-0389, 108-1083570-3611
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.springerlink.com/content/f0m8578x737488wh/fulltext.pdf
Broj citata:
Altmetric:
DOI: 10.1007/s00595-006-3498-9
URL cjelovitog teksta:
Google Scholar: Stable Gastric Pentadecapeptide BPC 157 in Trials for Inflammatory Bowel Disease (PL-10, PLD-116, PL14736, Pliva, Croatia) Heals Ileoileal Anastomosis in the Rat
Upisao u CROSBI: psikiric@mef.hr (psikiric@mef.hr), 8. Lip. 2009. u 18:24 sati



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