engleski

On the Occasion of 10 Years of Prostatitis Research

This research is a part of several scientific research projects of the Ministry of Science, Education and Sports of the Republic of Croatia. The study was conducted at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases „ dr. Fran Mihaljević“ Zagreb, Croatia, between March 1, 1999 and February 28, 2009. The Ethics Committee of the Hospital approved the study. An informed consent was signed by all the patients. We examined a total of 3463 patients over 18 years of age with symptoms of chronic prostatitis and no evidence of structural or functional lower genitourinary tract abnormalities. The inclusion criteria for chronic prostatitis was the duration of one or more symptoms for at least 3 months. The following data were obtained for each patient: medical history, clinical status including digitorectal prostatic examination, urethral swab specimens and selective samples of urine and EPS in 4-glass localization technique. Urethral swab specimens and EPS or VB3 were examined for the presence of C.trachomatis, U.urealyticum, M.hominis and T.vaginalis. Quantitative segmented cultures, bacterial identification and the number of leukocytes were determined in three voided urine samples and expressed prostatic secretion. An infectious etiology was determined in 1475 (66%) of a total of 2218 patients with inflammatory chronic prostatitis syndrome. C.trachomatis was the causative pathogen in 320 (14%), Trichomonas vaginalis in 11%, E.coli in 10%, Enterococcus in 9%, U.urealyticum in 8%, P.mirabilis in 4%. A high incidence of etiologically confirmed chronic prostatitis syndrome cases, especially high percentage of sexually transmitted pathogens, can be explained through: 1) selective population referred to our outpatient department due to a suspected urogenital or sexually transmitted infection and 2) regular analysis in these patients for the presence of C.trachomatis, U.urealyticum, M.hominis and T.vaginalis with the most sophisticated microbiological methods. A total of 307 patients with chronic prostatitis caused by C.trachomatis and 82 caused by U.urealyticum were treated with azithromycin in a total dose of 4.0, 4.5 or 6.0 g. Comparative drugs were ciprofloxacin, clarithromycin and doxycycline. Azithromycin is an efficient and safe antimicrobial drug for the treatment of chronic prostatitis caused by C.trachomatis and U.urealyticum. It is recommended in a total dose of 4.5 g p.o. during 3 weeks, administered for 3 days in doses 1x500 mg per day or in a total dose of 4.0 g p.o. during 4 weeks, administered in a single dose of 1x1.0 g per week.

prostatitis

nije evidentirano