crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 415920

Časopis

Autori: Boban, Nataša; McCallum, J. B.; Schedewie, H. K.; Boban, Mladen; Kampine, J. P.; Bošnjak, Željko J.
Naslov: Direct comparative effects of isoflurane and desflurane on sympathetic ganglionic transmission
( Direct comparative effects of isoflurane and desflurane on sympathetic ganglionic transmission )
Izvornik: Anesthesia and analgesia (0003-2999) 80 (1995); 127-134
Vrsta rada: članak
Ključne riječi: isoflurane; desflurane; ganglion stellatum; ganglionic transmission
( isoflurane; desflurane; ganglion stellatum; ganglionic transmission )
Sažetak:
Although the sympathetic ganglion is an important site of peripheral regulation, few studies have examined the effect of anesthetics on synaptic transmission. In the present study we compared the actions of desflurane with those of isoflurane on synaptic transmission and neurotransmitter release in the stellate ganglion. In the electrophysiologic group, 14 stellate ganglia were isolated from adult mongrel dogs after halothane anesthesia, desheathed, and superfused with Krebs' solution. Compound action potentials (CAP) were induced by supramaximal stimulation of the preganglionic T3-ramus at a low frequency of 0.4 Hz and were recorded from the postganglionic ventral ansa subclaviae. Each ganglion was exposed to two levels of anesthetics (equivalent to 1 and 2 minimum alveolar anesthetic concentration [MAC]), followed by an anesthetic-free washout period. While equianesthetic concentrations of isoflurane and desflurane caused essentially equipotent suppression of ganglionic transmission, desflurane was more efficacious than isoflurane, both with respect to the onset of and recovery from the inhibition of synaptic activity. In the electrochemical group, 25 ganglia were exposed to both anesthetics at a high concentration (equivalent to between 1.82 and 1.95 MAC) during maximal and submaximal current stimulations, and the release of actylcholine (ACh) in the superfusate was measured with liquid chromatography. Although desflurane and isoflurane caused a significant depression of CAP, neither anesthetic inhibited the release of ACh in the superfusate at either maximal or submaximal current stimulations. These results indicate that the suppression of ganglionic activity is equipotent for both anesthetics based on equivalent MAC values, but that desflurane is more efficacious than isoflurane with respect to onset and recovery at the higher concentrations of anesthetics
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.anesthesia-analgesia.org/content/80/1/127.full.pdf+html
URL cjelovitog teksta:
Google Scholar: Direct comparative effects of isoflurane and desflurane on sympathetic ganglionic transmission
Upisao u CROSBI: mboban@mefst.hr (mboban@mefst.hr), 12. Lip. 2009. u 15:26 sati



  Verzija za printanje   za tiskati


upomoc
foot_4