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Pregled bibliografske jedinice broj: 416545

Časopis

Autori: Wang, W.; Li, C.; Summer, S.N.; Falk, S.; Wang, W.; Ljubanović, Danica; Schrier, R.W.
Naslov: Role of AQP1 in endotoxemia-induced acute kidney injury
( Role of AQP1 in endotoxemia-induced acute kidney injury )
Izvornik: American journal of physiology. Renal physiology (1931-857X) 294 (2008), 6; F1473-14801
Vrsta rada: članak
Ključne riječi: lipopolysaccharide; sepsis; glomerular filtration rate; polyuria; aquaporin-1
( lipopolysaccharide; sepsis; glomerular filtration rate; polyuria; aquaporin-1 )
Sažetak:
The effect of endotoxemia (lipopolysaccharide, 2.5 mg/kg ip) was investigated in aquaporin (AQP) 1 knockout (KO) compared with wild-type (WT) mice. At baseline, KO mice exhibited higher water intake (WI) and urine output (UO). After endotoxemia, WI and UO remained higher in the KO than WT mice, and urine osmolality was lower. The higher serum osmolality in AQP1-KO mice during endotoxemia was associated with higher AQP2 (133 ± ; 8 vs. 100 ± ; 3%, P < 0.01), AQP3 (140 ± ; 8 vs. 100 ± ; 4%, P < 0.001) and Na+-K+-2Cl– cotransporter type 2 (NKCC2 ; 152 ± ; 14 vs. 100 ± ; 15%, P < 0.05) expression than that in WT mice. These responses during endotoxemia in the AQP1-KO mice compared with WT were associated with lower glomerular filtration rate (GFR) (69 ± ; 8 vs. 96 ± ; 8 ml/min, P < 0.05) and renal blood flow (0.77 ± ; 0.1 vs. 1.01 ± ; 0.1 ml/min, P < 0.01). Urinary sodium excretion and fractional sodium excretion were higher in KO compared with WT mice in endotoxemia and were accompanied by more severe tubular injury. With water repletion and comparable serum osmolalities, GFR was still lower in KO (57 ± ; 13 vs. 120 ± ; 6 ml/min, P < 0.01) compared with WT during endotoxemia. The abundance of AQP2 and AQP3 protein in KO mice was not different from WT mice ; however, NKCC2, Na+/H+ exchanger type 3, and fractional sodium excretion remained higher in KO compared with WT. Thus the polyuria in AQP1-KO mice does not protect against endotoxemia-induced acute kidney injury but rather absence of AQP1 predisposed to enhanced endotoximic renal injury.
Projekt / tema: 198-0000000-3355
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://ajprenal.physiology.org/cgi/reprint/294/6/F1473
Broj citata:
Altmetric:
DOI: 10.1152/ajprenal.00036.2008
URL cjelovitog teksta:
Google Scholar: Role of AQP1 in endotoxemia-induced acute kidney injury
Upisao u CROSBI: dljubanovic@mef.hr (dljubanovic@mef.hr), 13. Lip. 2009. u 21:54 sati



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