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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 427553

Časopis

Autori: Mudnić, Ivana; Modun, Darko; Rastija, Vesna; Vuković, Jonatan; Brizić, Ivan; Katalinić, Višnja; Kozina, Bernard; Medić-Šarić, Marica; Boban, Mladen
Naslov: Antioxidative and vasodilatory effects of phenolic acids in wine
( Antioxidative and vasodilatory effects of phenolic acids in wine )
Izvornik: Food chemistry (0308-8146) 119 (2010), 3; 1205-1210
Vrsta rada: članak
Ključne riječi: Phenolic acids; Vasodilation; Antioxidative activity; Wine; Quantitative structure activity relationship
( Phenolic acids; Vasodilation; Antioxidative activity; Wine; Quantitative structure activity relationship )
Sažetak:
Phenolic acids represent important fraction of wine phenolics, but their biological effects have been scarcely investigated. We examined interrelationship between antioxidative capacity and vasodilatory activity, two potentially beneficial biological effects, of 9 phenolic acids from wine. The observed antioxidative and vasodilatory effects of the tested phenolic acids were further evaluated through quantitative structure-activity relationship (QSAR) analysis, by using molecular properties, “ two-dimensional” (2D) and “ three-dimensional” (3D) molecular descriptors. The antioxidative capacity of phenolic acids was measured by Ferric Reducing Antioxidant Power (FRAP) and Trolox Equivalent Antioxidant Capacity (TEAC) methods whereas their vasodilatory activity was determined in the precontracted rat aortic rings. FRAP and TEAC values for antioxidative capacity positively correlated, but antioxidative capacity and maximal vasodilatory effect of the acids showed a negative correlation. This was best illustrated by poor vasodilatory activity of gallic acid, which is the strongest antioxidant among the tested phenolic acids. QSAR study described how antioxidative and vasodilatory effects of phenolic acids relate to number of hydroxyl groups in the phenyl ring, degree of compactness and branching of molecules, and three-dimensional distributions of atomic polarizability of the tested molecules.
Projekt / tema: 216-2160547-0537, 011-2160547-2226, 006-0061117-1237
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Prehrambena tehnologija
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0308814609010310
http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271163&_user=3875467&_pii=S0308814609010310&_check=y&_origin=browse&_coverDate=01-Apr-2010&view=c&wchp=dGLzVlS-zSkWA&md5=bd54ebaa7641785a8ba6bd6228ac99ea/1-s2.0-S0308814609010310-main.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.foodchem.2009.08.038
URL cjelovitog teksta:
Google Scholar: Antioxidative and vasodilatory effects of phenolic acids in wine
Upisao u CROSBI: imudnic@mefst.hr (imudnic@mefst.hr), 23. Ruj. 2009. u 01:48 sati



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