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Pregled bibliografske jedinice broj: 428396

Zbornik radova

Autori: Grebić, Damir; Jakovac, Hrvoje; Tota, Marin; Barac-Latas, Vesna; Milin, Čedomila; Mrakovčić-Šutić, Ines; Radošević-Stašić, Biserka
Naslov: Hepatic metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis in rats
( Hepatic metallothioneins and tissue metals in chronic relapsing form of experimental autoimmune encephalomyelitis in rats )
Izvornik: 2nd European Congress of Immunology / Reinhold E. Schmidt (ur.). - Bologna : Medimond Monduzzi Editore , 2009. 291-297 (ISBN: 978-88-7587-522-0).
Skup: 2nd European Congress of Immunology
Mjesto i datum: Berlin, Njemačka, 13-16.09.2009.
Ključne riječi: liver; metallothioneins; zinc; copper; chronic relapsing encephalomyelitis; DA rats
( liver; metallothioneins; zinc; copper; chronic relapsing encephalomyelitis; DA rats )
Sažetak:
Metallothioneins (MTs) are low molecular weight, cysteine-rich proteins that can act as antioxidants and as the immunosuppressive agents in instances of antigen-dependent adaptive immunity. Their induction dramatically increases in response to tissue injury, infection, inflammation and neoplastic disease, showing that they belong to a stress or acute phase proteins. To elucidate the participation of the liver in the pathogenesis of chronic relapsing form of experimental autoimmune encephalomyelitis (CR-EAE), induced in the genetically susceptible DA rats, in this study the hepatic expression of MT I+II and tissue concentrations of Zn2+ and Cu2+ were evaluated during the different phases of disease (in attacks on the 12th and 22nd and remissions on the 18th and 28th post-immunization day). The data revealed that hepatic expression of MTs was markedly enhanced during the time of attacks, as well as that during the first attack of EAE significantly arose the hepatic concentrations Zn2+ and Cu2+ (p<0.0003 in comparison with CFA-treated rats), pointing to the direct participation of the liver in CR-EAE.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Cjeloviti rad (više od 1500 riječi)
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0621341-1337, 062-0621341-0061
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: biserr@medri.hr (biserr@medri.hr), 29. Ruj. 2009. u 12:37 sati



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