engleski

Antimicrobial resistance of Streptococcus pneumoniae isolates

Streptococcus pneumoniae (S. pneumoniae) is the major pathogen isolated in community-acquired respiratory tract infections, being the causative agent of variety of infections, such as pneumonia, sinusitis and acute otitis media. The development of antimicrobial resistance in S. pneumoniae over the last two decades has raised a global concern, an evolution generally atributed to an extensive consumptions of antibiotics. The nasopharynx of preschool children is the ecological niche of S. pneumoniae. Nasopharyngeal colonization is a prerequisite for progression to pneumococcal disease and an important source of horizontal spread in the community. The aim of this study was to determine the prevalence of antimicrobial resistance of S. pneumoniae isolates of outpatients in Primorsko-Goranska County during the period 2003-2008. S. pneumoniae was isolated from 3183/46958 (6, 8%) specimens. Susceptibility to analyzed antibiotics was tested using the disk diffusion method. In isolates with reduced sensitivity to penicillin (as determined with oxacillin disk method)minimal inhibitory concentrations (MICs) of penicillin were tested by E-test (AB Biodisk) method. Analyzed S. pneumoniae demonstrated decreased susceptibility to penicillin in 675 cases (21% of all isolates), no high level resistance to penicillin and no resistance to quinolones. Isolates with reduced sensitivity to penicillin had MICs from 0.125 to 1.5 micrograms/mL. Resistance of S. pneumoniae isolates to all other antibiotics tested wasn't dramatically changed.

Streptococcus pneumoniae; antibiotics; resistance

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