engleski

4-Hydroxynonenal-protein adducts as biomarkers of oxidative stress, lipid peroxidation and oxidative homeostasis

Lipid peroxidation and its end products reactive aldehydes are implicated in pathogenesis of various diseases such as cardiovascular diseases, neurodegenerative diseases, diabetes mellitus and cancer. 4-hydroxy-2-nonenal (HNE) is the most intriguing one due to its involvement in various (patho)physiological processes. The concept of HNE as toxic messenger of free radicals evolved further into the concept of HNE as biomarker, growth regulating factor and signalling molecule. That allowed consideration of oxidative stress also as physiological process introducing new term ”oxidative homeostasis”, which implies involvements of reactive oxygen species (ROS) and lipid peroxidation in various physiological processes. According to such concept of oxidative homeostasis, the HNE-protein adducts should be present not only under pathological but also under physiological circumstances in various human and animal tissues, as revealed in this article showing briefly results of several genuine immunohistochemical studies.

4-hydroxynonenal; lipid peroxidation; oxidative stress; oxidative homeostasis

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