crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 437669

Časopis

Autori: Wlodarski, Tomasz; Žagrović, Bojan
Naslov: Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin
Izvornik: Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 106 (2009), 46; 19346-19351
Vrsta rada: članak
Ključne riječi: ubiquitin binding; protein recognition; Kolmogorov–Smirnov test
Sažetak:
Noncovalent binding interactions between proteins are the central physicochemical phenomenon underlying biological signaling and functional control on the molecular level. Here, we perform an extensive structural analysis of a large set of bound and unbound ubiquitin conformers and study the level of residual induced fit after conformational selection in the binding process. We show that the region surrounding the binding site in ubiquitin undergoes conformational changes that are significantly more pronounced compared with the whole molecule on average. We demonstrate that these induced-fit structural adjustments are comparable in magnitude to conformational selection. Our final model of ubiquitin binding blends conformational selection with the subsequent induced fit and provides a quantitative measure of their respective contributions.
Projekt / tema: 177-1770495-0476
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)

MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Fizika,Biologija
Puni text rada: 437669.wlodarski2009.pdf (tekst priložen 15. Pro. 2009. u 21:37 sati)
URL Internet adrese: http://www.pnas.org/content/106/46/19346.long
Broj citata:
Altmetric:
DOI: 10.1073/pnas.0906966106
URL cjelovitog teksta: http://www.pnas.org/content/106/46/19346.long
Google Scholar: Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin
Upisao u CROSBI: juretic@pmfst.hr (juretic@pmfst.hr), 15. Pro. 2009. u 21:37 sati



  Verzija za printanje   za tiskati


upomoc
foot_4