crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 437959

Zbornik radova

Autori: Juretić, Davor
Naslov: Selectivity prediction for frog-type peptide antibiotics against Gram-negative bacteria
Izvornik: The 3rd Adriatic Meeting on Computational Solutions in the Life Sciences / Tomić, Sanja ; Smith, David (ur.). - Zagreb : Centre for Computational Solutions in the Life Sciences, Ruđer Bošković Institute , 2009. 40-40 (ISBN: 978-953-6690-80-0).
Skup: The 3rd Adriatic Meeting on Computational Solutions in the Life Sciences
Mjesto i datum: Primošten, Hrvatska, 1-5.09.2009.
Ključne riječi: peptide antibiotics; selectivity prediction
Sažetak:
We have developed the D-descriptor model for predicting the therapeutic index (TI) of frog-derived antimicrobial peptides (AMPs). It is linear one-parameter model which produces high correlation among predicted and measured TI (r2=0.83) for almost forty non-homologous AMPs. The single parameter used is cosine of the angle between two sequence moments for given peptide sequence bent in the π/2 arc. In the case of pseudin 2 measured and predicted TI are 6 and 7 (for separation angle of 15 degrees between sequence moments) respectively, but single point mutation (N3K) has dramatic effect in increasing TI to measured and predicted value of 34 and 36 (for separation angle of 72 degrees between sequence moments) respectively. We shall discuss sequence moments definition and relevance of this research for finding novel antibiotics with little likelihood to elicit bacterial resistance development.
Vrsta sudjelovanja: Pozvano
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 177-1770495-0476
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Fizika,Biologija
Upisao u CROSBI: juretic@pmfst.hr (juretic@pmfst.hr), 17. Pro. 2009. u 23:58 sati



Verzija za printanje   za tiskati


upomoc
foot_4