crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 440683

Časopis

Autori: Racané, Livio; Tralić-Kulenović, Vesna; Kraljević Pavelić, Sandra; Ratkaj, Ivana; Peixoto, Paul; Nhili, Raja; Depauw, Sabine; Hildebrand, Marie-Paule; David-Cordonnier, Marie-Hélène; Pavelić, Krešimir; Karminski-Zamola, Grace
Naslov: Novel Diamidino-Substituted Derivatives of Phenyl-Benzothiazolyl- and Dibenzothiazolyl-Furans and Thiophenes : Synthesis, Antiproliferative and DNA binding Properties
Izvornik: Journal of medicinal chemistry (0022-2623) 53 (2010), 5; 2418-2432
Vrsta rada: članak
Ključne riječi: diamidines; furans; thieophenes; antitumor activizy; DNA binding; sequence-selectivity; celllular distribuction; spectroscopic identification
Sažetak:
A series of new diamidino, diisopropylamidino and diimidazolinyl substituted derivatives of phenyl-benzothiazolyl- and dibenzothiazolyl-furans and -thiophenes were successfully prepared and evaluated for their antiproliferative activity on tumour cell lines in vitro, DNA binding propensity and sequence-selectivity as well as cellular distribution. A strong antiproliferative effect of the tested compounds was observed on all tested cell lines in a concentration-dependent response pattern. In general, imidazolinyl-substituded derivatives and/or the thiophene core were in correlation with increased antiproliferative activity. Two compounds (2b and 3b) were chosen for biological studies due to their differential antiproliferative properties. The DNA binding properties of this new series of compounds were assessed and evidenced their efficient minor groove binding properties with preferential interaction at AT-rich sites. Both compounds also present nuclear sub-cellular localization, suggesting that their cellular mode of action implies localization in the DNA compartment and direct inhibition of DNA replication and induction of apoptosis.
Projekt / tema: 125-0982464-1356, 335-0982464-2393, 117-0000000-3283, 335-0000000-3532
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija
URL Internet adrese: http://pubs.acs.org/doi/pdf/10.1021/jm901441b
http:///pubs.acs.org/doi/pdfplus/10.1021/jm901441b
URL cjelovitog teksta:
Google Scholar: Novel Diamidino-Substituted Derivatives of Phenyl-Benzothiazolyl- and Dibenzothiazolyl-Furans and Thiophenes : Synthesis, Antiproliferative and DNA binding Properties
Upisao u CROSBI: gkzam@fkit.hr (gkzam@fkit.hr), 19. Sij. 2010. u 10:34 sati



  Verzija za printanje   za tiskati


upomoc
foot_4