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Pregled bibliografske jedinice broj: 443697

Časopis

Autori: Sedić, Mirela; Jurišić, Davor; Stanec, Zdenko; Hock, Karlo; Pavelić, Krešimir; Kraljević Pavelić, Sandra
Naslov: Functional genomics in identification of drug targets in Dupuytren's contracture.
Izvornik: Frontiers in bioscience (1093-9946) 15 (2010); 57-64
Vrsta rada: pregledni rad
Ključne riječi: Dupuytren's contracture; bioinformatics; functional genomics
Sažetak:
Although functional genomics methods offer new viewpoint on molecular processes involved in particular pathological state, these methods, in particular proteomics, are still under-represented in Dupuytren's contracture research. However, several recent papers based on functional genomics technologies represent a breakthrough in studying Dupuytren's contracture as they revealed new molecular players that had been impossible to detect by traditional molecular biology methods. Using computational tools to provide biological context for such broad arrays of data accelerates the process of homing in on the potential molecular markers and drug targets. Interactomes, maps of protein-protein interactions characteristic for the disease and as such putative models of its molecular pathology, are especially useful for this purpose, facilitating the transition from global screening methods to specific experiments aimed at therapy development. The combination of these approaches in Dupuytren's contracture research might therefore facilitate the discovery of novel therapeutic targets and diagnostic markers indicative of disease progression.
Projekt / tema: 14V09809, 098-0982464-2393
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL cjelovitog teksta:
Google Scholar: Functional genomics in identification of drug targets in Dupuytren's contracture.
Upisao u CROSBI: sandrakp@uniri.hr (sandrakp@uniri.hr), 8. Vel. 2010. u 20:50 sati



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