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Zbornik radova

Autori: Basarić, Nikola; Žabčić, Ivana; Cindro, Nikola; Mlinarić-Majerski, Kata; Wan, Peter
Naslov: Photochemistry of adamantyl phenols: Synthesis of long-lived quinone methides
Izvornik: Central European Conference on Photochemistry (CECP 2010) : abstracts
Skup: Central European Conference on Photochemistry
Mjesto i datum: Bad Hofgastein, Austrija, 07.-11.02.2010.
Ključne riječi: Quinone methides; fluorescence; adamantyl-phenols
Sažetak:
Quinone methides (QM) are important intermediates in chemistry and photochemistry of phenols [1]. They are known as DNA alkylating agents ; hence they are potential drugs for treating cancer. Photochemical reaction of some hydroxyalklyphenols is a powerful method for generating QMs [2]. However, most of QMs are charcaterized by short lifetimes (μs-ms range) so they are not applicable in biological systems. In the scope of our research on derivatisation of adamantyl derivatives for the preparation of biologically active molecules we turned our attention to adamantyl-phenols and their potential utility to photochemically generate QMs that would be characterized by longer lifetimes. The phenols were therefore strategically substituted by 2-hydroxyl-2-adamantyl moiety (1-3). On excitation of these derivatives dehydratation is taking place giving rise to QMs. The reaction mechanism was investigated by performing product study, fluorescence and laser flash photolysis.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 098-0982933-2911
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: eluksa@irb.hr (eluksa@irb.hr), 16. Vel. 2010. u 09:58 sati



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