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Pregled bibliografske jedinice broj: 449303

Časopis

Autori: Gjurašin, Miroslav; Miklić, Pavle; Župančić, Božidar; Perović, Darko; Žarković, Kamelija; Brčić, Luka; Kolenc, Danijela; Radić, Božo; Seiwerth, Sven; Sikirić, Predrag
Naslov: Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury
Izvornik: Regulatory peptides (0167-0115) 160 (2010), 1/3; 33-41
Vrsta rada: članak
Ključne riječi: pentadecapeptide BPC 157; rat; transected nerve
Sažetak:
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 µg, 10 ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube. Improvement was shown clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals). BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers, existence of epineural and perineural regeneration, uniform target orientation of regenerative fibers, and higher proportion of neural vs. connective tissue, all fascicles in each nerve showed increased diameter of myelinated fibers, thickness of myelin sheet, number of myelinated fibers per area and myelinated fibers as a percentage of the nerve transected area and the increased blood vessels presentation), electrophysiologically (increased motor action potentials), functionally (improved SFI), the autotomy absent. Thus, BPC 157 markedly improved rat sciatic nerve healing.
Projekt / tema: 108-1083570-3643, 108-0000000-0028, 098-0982464-2519, 108-1083570-3635, 108-1080231-0324
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: ttp://dx.doi.org/10.1016/j.regpep.2009.11.005
http://www.sciencedirect.com/science/article/pii/S0167011509002274
http://ac.els-cdn.com/S0167011509002274/1-s2.0-S0167011509002274-main.pdf?_tid=0837fc34-28dd-11e2-bb09-00000aacb362&acdnat=1352294236_2802fc2de80e84a7e729aec0b7da8a97
Broj citata:
Altmetric:
DOI: 10.1016/j.regpep.2009.11.005
URL cjelovitog teksta: ttp://dx.doi.org/10.1016/j.regpep.2009.11.005
Google Scholar: Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 19. Ožu. 2010. u 14:06 sati



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