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izvor podataka: crosbi

HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats (CROSBI ID 159956)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Marquez-Quiñones, Adriana ; Čipak, Ana ; Žarković, Kamelija ; Fattel-Fazenda, Samia ; Villa-Treviño, Saul ; Waeg, Georg ; Žarković, Neven ; Guéraud, Françoise HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats // Free radical research, 44 (2010), 2; 119-127. doi: 10.3109/10715760903338071

Podaci o odgovornosti

Marquez-Quiñones, Adriana ; Čipak, Ana ; Žarković, Kamelija ; Fattel-Fazenda, Samia ; Villa-Treviño, Saul ; Waeg, Georg ; Žarković, Neven ; Guéraud, Françoise

engleski

HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats

Lipid peroxidation is highly associated with chronic degenerative diseases such as cancer. 4-hydroxy-2-nonenal is one of the major products of lipid peroxidation. 4-hydroxy-2-nonenal can interact with biomolecules, changing their conformation and activity. This study presents 4-hydroxy-2-nonenal-protein adducts formation in the first stages of Long-Evans Cinnamon rat hepatitis, a well recognized model for oxidative stress-associated hepatocarcinogenesis. 4-hydroxy-2-nonenal-protein adducts appeared in hepatocyte cytoplasm before the beginning of hepatitis and their presence was very strong during hepatitis, while a transient perinuclear expression of 4-hydroxy-2-nonenal-protein adducts was shown mainly at early hepatitis stages. 4-hydroxy-2-nonenal-protein adducts formation correlated to the expression of the tumour marker glutathione S-transferase P-form. These results show that lipid peroxidation modification of proteins might be implicated in the first stages of hepatocyte cancer initiation in Long-Evans Cinnamon rats.

hepatitis; LEC rats; HNE; oxidative stress

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Podaci o izdanju

44 (2)

2010.

119-127

objavljeno

1071-5762

10.3109/10715760903338071

Povezanost rada

Temeljne medicinske znanosti

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