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Pregled bibliografske jedinice broj: 449315

Časopis

Autori: Marquez-Quiñones, Adriana; Čipak, Ana; Žarković, Kamelija; Fattel-Fazenda, Samia; Villa-Treviño, Saul; Waeg, Georg; Žarković, Neven; Guéraud, Françoise
Naslov: HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats
Izvornik: Free radical research (1071-5762) 44 (2010), 2; 119-127
Vrsta rada: članak
Ključne riječi: hepatitis; LEC rats; HNE; oxidative stress
Sažetak:
Lipid peroxidation is highly associated with chronic degenerative diseases such as cancer. 4-hydroxy-2-nonenal is one of the major products of lipid peroxidation. 4-hydroxy-2-nonenal can interact with biomolecules, changing their conformation and activity. This study presents 4-hydroxy-2-nonenal-protein adducts formation in the first stages of Long-Evans Cinnamon rat hepatitis, a well recognized model for oxidative stress-associated hepatocarcinogenesis. 4-hydroxy-2-nonenal-protein adducts appeared in hepatocyte cytoplasm before the beginning of hepatitis and their presence was very strong during hepatitis, while a transient perinuclear expression of 4-hydroxy-2-nonenal-protein adducts was shown mainly at early hepatitis stages. 4-hydroxy-2-nonenal-protein adducts formation correlated to the expression of the tumour marker glutathione S-transferase P-form. These results show that lipid peroxidation modification of proteins might be implicated in the first stages of hepatocyte cancer initiation in Long-Evans Cinnamon rats.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://informahealthcare.com/doi/abs/10.3109/10715760903338071
http://informahealthcare.com/doi/pdf/10.3109/10715760903338071
Broj citata:
Altmetric:
DOI: 10.3109/10715760903338071
URL cjelovitog teksta:
Google Scholar: HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 19. Ožu. 2010. u 14:18 sati



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