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Pregled bibliografske jedinice broj: 450983

Časopis

Autori: Mrakovčić, Lidija; Wildburger, Renate; Jaganjac, Morana; Cindrić, Marina; Čipak, Ana; Borović Šunjić, Suzana; Waeg, Georg; Mogus Milanković, Andrea; Žarković, Neven
Naslov: Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses
Izvornik: Acta biochimica Polonica (0001-527X) 57 (2010), 2; 173-178
Vrsta rada: članak
Ključne riječi: bone regeneration; bioactive glass; lipid peroxidation; 4-hydroxynonenal; oxidative homeostasis
Sažetak:
Bone regeneration is a process of vital importance since factures of long bones and large joints have a highly deleterious impact on life of individual and society. Various attempts are done to solve this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Since lipid peroxidation was defined as important parameter of systematic stress response in patients with traumatic brain injuries and bone fractures it led to recent studies of molecular mechanisms of 4-hydroxynonenal (HNE), end product of lipid peroxidation, associated with cellular growth regulation. We have found that HNE is generating in bone cells while grown in vitro on the surfaces of bioactive glasses 45S5 and 13-93. This raises interesting hypothesis of combined action of HNE and bioglass ionic dissolution products in enhanced osteogenesis probably through mitogen-activated protein kinase (MAPK) pathway. While proposed mechanism still has to be elucidated, the finding of HNE generated on bioglass offers new interpretation of osteoinducting mechanisms of bioglass and suggests promising tools in future tissue engineering based on oxidative homeostasis.
Projekt / tema: 098-0982929-2916, 108-0000000-0028, 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://www.actabp.pl/pdf/2_2010/179.pdf
URL cjelovitog teksta:
Google Scholar: Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 23. Ožu. 2010. u 15:42 sati



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