crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 451245

Časopis

Autori: Tudor, Mario; Jandrić, Ivan; Marović, Anton; Gjurašin, Miroslav; Perović, Darko; Radić, Božo; Boban Blagaić, Alenka; Kolenc, Danijela; Brčić, Luka; Žarković, Kamelija; Seiwerth, Sven; Sikirić, Predrag
Naslov: Traumatic brain injury in mice and pentadecapeptide BPC 157 effect
Izvornik: Regulatory peptides (0167-0115) 160 (2010), 1/3; 26-32
Vrsta rada: članak
Ključne riječi: traumatic brain injury; pentadecapeptide BPC 157; mice
Sažetak:
Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported, improved muscle crush injury. After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0 µg, 10.0 ng/kg i.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24 h post-injury period. Ultimately, the traumatic lesions (subarachnoidal and intraventricular haemorrhage, brain laceration, haemorrhagic laceration) were less intense and consecutive brain edema had considerably improved. Given prophylactically (30 min before TBI) the improved conscious/unconscious/death ratio in TBI-mice was after force impulses of 0.068 N s, 0.093 N s, 0.113 N s, 0.130 N s, 0.145 N s, and 0.159 N s. Counteraction (with a reduction of unconsciousness, lower mortality) with both µg- and ng-regimens included the force impulses of 0.068–0.145 N s. A higher regimen presented effectiveness also against the maximal force impulse (0.159 N s). Furthermore, BPC 157 application immediately prior to injury was beneficial in mice subjected to force impulses of 0.093 N s-TBI. For a more severe force impulse (0.130 N s, 0.145 N s, or 0159 N s), the time-relation to improve the conscious/unconscious/death ratio was: 5 min (0.130 N s-TBI), 20 min (0.145 N s-TBI) or 30 min (0.159 N s-TBI).
Projekt / tema: 108-1083570-3635, 098-0982464-2519, 108-0000000-0028, 108-1083570-3643
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://dx.doi.org/10.1016/j.regpep.2009.11.012
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T0S-4XR5MXS-3-5&_cdi=4870&_user=3875467&_pii=S0167011509002341&_orig=browse&_coverDate=02%2F25%2F2010&_sk=998399998&view=c&wchp=dGLzVzb-zSkWA&md5=06901a56d8c7df2f4ebd3d9e5b34ebce&ie=/sdarticle.pdfhttp://www.sciencedirect.com/science/article/pii/S0167011509002341
http://ac.els-cdn.com/S0167011509002341/1-s2.0-S0167011509002341-main.pdf?_tid=815e69c2-28dd-11e2-9431-00000aacb35d&acdnat=1352294439_a34be9b0943be3bfa50d3609a259852c
Broj citata:
Altmetric:
DOI: 10.1016/j.regpep.2009.11.012
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.regpep.2009.11.012
Google Scholar: Traumatic brain injury in mice and pentadecapeptide BPC 157 effect
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 24. Ožu. 2010. u 09:45 sati



  Verzija za printanje   za tiskati


upomoc
foot_4