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Pregled bibliografske jedinice broj: 451429

Časopis

Autori: Kašuba, Vilena; Rozgaj, Ružica; Milić, Mirta; Želježić, Davor; Kopjar, Nevenka; Pizent, Alica; Kljaković-Gašpić, Zorana
Naslov: Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers
( Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers )
Izvornik: JAT. Journal of applied toxicology (0260-437X) 30 (2010), 4; 321-328
Vrsta rada: članak
Ključne riječi: battery workers; micronuclei; blood lead and cadmium level; serum folate; serum Vitamin B12; delta aminolevulinic acid dehydratase; erythrocyte protoporphyrin
( battery workers; micronuclei; blood lead and cadmium level; serum folate; serum Vitamin B12; delta aminolevulinic acid dehydratase; erythrocyte protoporphyrin )
Sažetak:
The influence of exposure to lead on the frequency of micronuclei (MN), nuclear buds and nucleoplasmatic bridges was investigated in peripheral blood lymphocytes in 15 male battery-manufacturing workers and 15 controls matched for age and smoking habits. In addition to MN test, blood lead (B-Pb) and cadmium (B-Cd), delta aminolevulinic acid dehydratase (ALAD) activity, erythrocyte protoporphyrin (EP), serum vitamin B12 (S-Vit B12) and folate (S-folate) were determined in all subjects. Lead-exposed subjects had significantly higher MN frequency and B-Pb concentrations than controls. In control smokers we found a significant negative correlation between B-Pb concentration and frequency of nucleoplasmatic bridges, and nuclear division index. In control non-smokers a significant positive correlation was observed only between age and nuclear buds frequency, and between S-folate and B-Pb level. In lead exposed smokers, significant positive correlations between MN frequency and S-Vit B12, S-folate, and nuclear buds frequency were found. A positive correlation in exposed smokers was also found between nuclear buds frequency and S-Vit B12 concentration. A negative correlation was found between ALAD and EP, and B-Pb in exposed smokers. Exposed non-smokers showed significant negative correlation between MN frequency and B-Cd, and ALAD and EP. The results indicate a genotoxicity of lead, pointing to a micronucleus assay as a relevant test for assessing genotoxic effects resulting from occupational exposure. The other indicators did not necessarily follow the results of MN test. Influence of smoking should be further investigated. Copyright Ó John Wiley & Sons, Ltd.
Projekt / tema: 022-0222148-2137, 022-0222411-2408
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija
URL Internet adrese: http://www3.interscience.wiley.com/journal/122688478/abstract
http://onlinelibrary.wiley.com/doi/10.1002/jat.1497/abstract
http://www3.interscience.wiley.com/journal/122688478/abstract
Broj citata:
Altmetric:
DOI: 10.1002/jat.1497
URL cjelovitog teksta: http://www3.interscience.wiley.com/journal/122688478/abstract
Google Scholar: Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers
Upisao u CROSBI: vkasuba@imi.hr (vkasuba@imi.hr), 24. Ožu. 2010. u 12:18 sati



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