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Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers (CROSBI ID 160431)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kašuba, Vilena ; Rozgaj, Ružica ; Milić, Mirta ; Želježić, Davor ; Kopjar, Nevenka ; Pizent, Alica ; Kljaković-Gašpić, Zorana Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers // JAT. Journal of applied toxicology, 30 (2010), 4; 321-328. doi: 10.1002/jat.1497

Podaci o odgovornosti

Kašuba, Vilena ; Rozgaj, Ružica ; Milić, Mirta ; Želježić, Davor ; Kopjar, Nevenka ; Pizent, Alica ; Kljaković-Gašpić, Zorana

engleski

Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers

The influence of exposure to lead on the frequency of micronuclei (MN), nuclear buds and nucleoplasmatic bridges was investigated in peripheral blood lymphocytes in 15 male battery-manufacturing workers and 15 controls matched for age and smoking habits. In addition to MN test, blood lead (B-Pb) and cadmium (B-Cd), delta aminolevulinic acid dehydratase (ALAD) activity, erythrocyte protoporphyrin (EP), serum vitamin B12 (S-Vit B12) and folate (S-folate) were determined in all subjects. Lead-exposed subjects had significantly higher MN frequency and B-Pb concentrations than controls. In control smokers we found a significant negative correlation between B-Pb concentration and frequency of nucleoplasmatic bridges, and nuclear division index. In control non-smokers a significant positive correlation was observed only between age and nuclear buds frequency, and between S-folate and B-Pb level. In lead exposed smokers, significant positive correlations between MN frequency and S-Vit B12, S-folate, and nuclear buds frequency were found. A positive correlation in exposed smokers was also found between nuclear buds frequency and S-Vit B12 concentration. A negative correlation was found between ALAD and EP, and B-Pb in exposed smokers. Exposed non-smokers showed significant negative correlation between MN frequency and B-Cd, and ALAD and EP. The results indicate a genotoxicity of lead, pointing to a micronucleus assay as a relevant test for assessing genotoxic effects resulting from occupational exposure. The other indicators did not necessarily follow the results of MN test. Influence of smoking should be further investigated. Copyright Ó John Wiley & Sons, Ltd.

battery workers; micronuclei; blood lead and cadmium level; serum folate; serum Vitamin B12; delta aminolevulinic acid dehydratase; erythrocyte protoporphyrin

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Podaci o izdanju

30 (4)

2010.

321-328

objavljeno

0260-437X

10.1002/jat.1497

Povezanost rada

Biologija

Poveznice
Indeksiranost