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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 451460

Časopis

Autori: Sever, Marko; Kliček, Robert; Radić, Božo; Brčić, Luka; Zoričić, Ivan; Drmić, Domagoj; Ivica, Mihovil; Barišić, Ivan; Ilić, Spomenko; Berkopić, Lidija; Boban Blagaić, Alenka; Ćorić, Marijana; Kolenc, Danijela; Vrčić, Hrvoje; Anić, Tomislav; Seiwerth, Sven; Sikirić, Predrag
Naslov: Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats
( Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats )
Izvornik: Digestive diseases and sciences (0163-2116) 54 (2009), 10; 2070-2083
Vrsta rada: članak
Ključne riječi: gastric pentadecapeptide BPC 157; short bowel syndrome; rats
( gastric pentadecapeptide BPC 157; short bowel syndrome; rats )
Sažetak:
The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth ileal artery cranially of ileocecal valve to 5 cm beneath pylorus. BPC 157 (10 microg/kg or 10 ng/kg) was given perorally, in drinking water (12 ml/rat/day) or intraperitoneally (once daily, first application 30 min following surgery, last 24 h before sacrifice). Postoperatively, features of increasingly exhausted presentation were: weight loss appearing immediately regardless of villus height, twofold increase in crypt depth and fourfold increase in muscle thickness within the first week, jejunal and ileal overdilation, and disturbed jejunum/ileum relation. In contrast, constant weight gain above preoperative values was observed immediately with BPC 157 therapy, both perorally and parenterally, and villus height, crypt depth, and muscle thickness [inner (circular) muscular layer] also increased, at 7, 14, 21, and 28 days. Moreover, rats treated with pentadecapeptide BPC 157 showed not different jejunal and ileal diameters, constant jejunum-to-ileum ratio, and increased anastomosis breaking strength. In conclusion, pentadecapeptide BPC 157 could be helpful to cure short bowel syndrome.
Projekt / tema: 108-1083570-3643, 108-0532264-0048, 108-1083570-3635, 108-1083570-3636, 108-1080321-0389
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://www.springerlink.com/content/f8304u01769x3488/?p=955be5d58b264a489bb2b59e0a505e07&pi=3
http://springerlink.metapress.com/content/f8304u01769x3488/resource-secured/?target=fulltext.pdf&sid=00laihqwvkt0aaawphjathju&sh=www.springerlink.com
Broj citata:
Altmetric:
DOI: 10.1007/s10620-008-0598-y
URL cjelovitog teksta:
Google Scholar: Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats
Upisao u CROSBI: lbrcic@mef.hr (lbrcic@mef.hr), 24. Ožu. 2010. u 12:40 sati



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