Re: Toth JM, Boden SD, Burkus JK, et al. Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment. Spine 2009 ; 34:539-50.
Spine (0362-2436) 35 (2010), 5; 597-598
recombinant human bone morphogenetic protein-2, lumbar interbody fusion, adverse effect, bone resorption
The local high rhBMP-2 concentration was suspected by Toth et al. as the reason for high incidence of the resorptions in some studies. However, there are reports, where even higher concentrations of rhBMP-2 were used, and no resorption was reported.
Projekt / tema:
Temeljne medicinske znanosti,Kliničke medicinske znanosti