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Pregled bibliografske jedinice broj: 455349

Rad u postupku objavljivanja

Autori: Puljiz, Ivan; Markotić, Alemka; Krajinović Cvetko, Lidija; Gužvinec, Marija; Kuzman, Ilija; Polašek, Ozren
Naslov: Role of interleukin-8 (IL-8), macrophage inflammatory proteins-1 beta (MIP-1B)and monocyte chemoattractant protein-1 (MCP-1) in pathogenesis of Mycoplasma pneumoniae community-acquired pneumonia
( Role of interleukin-8 (IL-8), macrophage inflammatory proteins-1 beta (MIP-1B)and monocyte chemoattractant protein-1 (MCP-1) in pathogenesis of Mycoplasma pneumoniae community-acquired pneumonia )
Izvornik: Chest (0012-3692) (2011)
Status rada: Poslan
Ključne riječi: Interleukin-8; macrophage inflammatory proteins-1; monocyte chemoattractant protein-1; Mycoplasma pneumoniae
( Iinterleukin-8; macrophage inflammatory proteins-1; monocyte chemoattractant protein-1; Mycoplasma pneumoniae )
Sažetak:
The objective of this study was to assess the concentration of interleukin-8 (IL-8), macrophage inflammatory proteins-1 (MIP-1), and monocyte chemoattractant protein-1 (MCP-1) in peripheral circulation and their mRNA expression in peripheral blood mononuclear leukocytes (MNLs) in patients with community acquired pneumonia (CAP) caused by Mycoplasma pneumoniae. We prospectively analyzed MMPs in 40 hospitalized patients with M. pneumoniae CAP on admission, and in the convalescent phase. Sera from 20 health male age between 15-50 years were used as controls. The gene expression in MNLs of IL-8 were greater in acute stage of M. pneumoniae CAP than in control group. Furthermore in convalescent gene expression was increased. The difference was statistical significant between patients in acute stage and convalescent regarding control group (p=0, 013 ; p=0, 001, respectively). Serum IL-8 concentration were higher in acute stage of pneumonia than in control group with statistical differences (p=0, 033). The gene expression of MCP-1 were on basal level in all examined group. However, serum concentration of MCP-1 was higher in control group than patients in acute and convalescent stage M. pneumoniae CAP. The difference was statistical significant between control group and patients in acute stage (p=0, 012). The gene expression of MIP1ß in MNLs were greater in acute stage of M. pneumoniae CAP than control group and convalescent stage with statistical difference (p>0, 001 ; p=0, 001, respectively). Serum MIP-1ß concentration were similiar patients in acute phase, reconvalescent and control group. Spearman`s correlation test in our patients showed correlation between gene expression of MIP1ß and neutrophil count in peripheral circulation (r=0, 40, p=0, 025). In conclusion, there was a associated between pathogenesis of CAP caused by M. pneumoniae and the develepment of IL-8 and MIP-ß mRNA expression in peripheral MNLs. Furthernmore, IL-8 plasma concentration suggest involved these chemokine in pathogenesis of disease. Plasma level of MCP-1 perhaps indicate escape in peripheral circulation and accumulation in pulmonary compartment.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Projekt / tema: 108-0000000-3491
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Upisao u CROSBI: ikuzman@bfm.hr (ikuzman@bfm.hr), 29. Ožu. 2010. u 21:31 sati



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