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Pregled bibliografske jedinice broj: 457274

Časopis

Autori: Blagaić, Vladimir; Houra, Karlo; Turčić, Petra; Štambuk, Nikola; Konjevoda, Paško; Boban-Blagaić, Alenka; Kelava, Tomislav; Kos, Marina; Aralica, Gorana; Čulo, Filip
Naslov: The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice
( The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice )
Izvornik: Molecules (1420-3049) 15 (2010), 3; 1232-1245
Vrsta rada: članak
Ključne riječi: melanocortins ; alpha-MSH ; beta-MSH ; gamma-MSH ; acetaminophen ; liver
( melanocortins ; alpha-MSH ; beta-MSH ; gamma-MSH ; acetaminophen ; liver )
Sažetak:
Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory andcytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dosedependent manner.
Projekt / tema: 098-0982929-2524, 108-0000000-0328
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti,Farmacija
URL Internet adrese: http://fulir.irb.hr/4423/
http://www.mdpi.com/1420-3049/15/3/1232/
https://doi.org/10.3390/molecules15031232
Broj citata:
Altmetric:
DOI: 10.3390/molecules15031232
URL cjelovitog teksta:
Google Scholar: The Influence of alpha-, beta-, and gamma-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice
Upisao u CROSBI: stambuk@irb.hr (stambuk@irb.hr), 31. Ožu. 2010. u 12:41 sati



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