engleski

METABOLIC RISK MARKERS IN WOMEN WITH POLYCYSTIC OVARIAN MORPHOLOGY

Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age, which is associated with a range of metabolic implications. Data concerning metabolic features of patients with polycystic ovarian morphology (POM) without any other PCOS diagnostic criteria (nonPCOS-POM) are limited. In the present study, metabolic profile of 46 women with nonPCOS-POM was investigated in comparison with 36 women with PCOS D phenotype and control group (N=146). PCOS D phenotype was defined according to the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM) criteria as irregular anovulatory periods and POM. NonPCOS-POM patients in comparison to PCOS-D phenotype group showed a significantly lower waist circumference (73.0 ; 17.0 ; 99.5 ; 11.0 ; P<0.001), a homeostatic model assessment of insulin resistance (HOMA-IR) (1.1 ; 1.0 ; 12.8 ; 6.9 ; P<0.001) and a significantly higher fasting glucose-insulin ratio (FGIR) (15.2 ; 13.0 ; 5.9 ; 3.4 ; P<0.001). There was no significant difference in waist circumference, FGIR and HOMAIR between the nonPCOS-PMO and control group. As neither PCOS-D phenotype nor nonPCOS-POM patients are characterized by hyperandrogenism, our data suggest that hyperandrogenism is not the only factor contributing to the increased metabolic risk in women with PCOS D phenotype. NonPCOS-POM patients share a similar metabolic risk profile with the control population and could not be considered as patients with an increased metabolic risk.

polycystic ovary syndrome; polycystic ovarian morphology; metabolic risk markers; hyperandrogenism

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