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Pregled bibliografske jedinice broj: 460827

Zbornik radova

Autori: Mihovilović, Karlo; Kardum-Skelin, Ika; Jelić Puškarić, Biljana; Ljubanović, Danica; Bulimbašić, Stela; Sabljar-Matovinović, Mirjana; Kovačević-Vojtušek, Ivana; Gracin, Sonja; Kocman, Branislav; Jadrijević, Stipe; Vidas, Željko; Guštin, Denis; Knotek, Mladen
Naslov: Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: A Single Center Experience
( Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: A Single Center Experience )
Izvornik: Knjiga sažetaka, 4. Hrvatski kongres kliničke citologije, 1. Hrvatski simpozij analitičke citologije i 2. Hrvatski simpozij citotehnologije s međunarodnim sudjelovanjem / Kardum-Skelin, Ika ; Batinić, Drago ; Anić, Veronika (ur.). - Zagreb : Hrvatsko društvo za kliničku citologiju HLZ, Sekcija za analitičku citologiju, Hrvatska udruga citotehnologa , 2009. .
Skup: 4. Hrvatski kongres kliničke citologije, 1. Hrvatski simpozij analitičke citologije i 2. Hrvatski simpozij citotehnologije s međunarodnim sudjelovanjem
Mjesto i datum: Split, Hrvatska, 11-14.10.2009.
Ključne riječi: renal transplantation; acute rejection; immunocytology; urinary sediment
( renal transplantation; acute rejection; immunocytology; urinary sediment )
Sažetak:
Aim - Renal biopsy is gold standard for diagnosing acute renal allograft rejection. Acute rejection may be associated with lymphocyte shedding in the urine. The aim of the present study was to evaluate diagnostic performance of urine immunocytology for CD3-positive cells in diagnosing renal allograft rejection. Participants and methods - This was a prospective single centre study performed in Clinical Hospital “Merkur”, Croatia. 54 kidney and kidney-pancreas transplant patients with 70 kidney biopsies (for cause or by protocol) and simultaneous urine immunocytologies (immunostaining for CD3) were included. Results - There were 24 AR cases, while in 46 biopsies AR was absent. Urine sediment was positive for CD3+ lymphocytes in 5 cases of AR (21%) and in 6 cases without AR (13%). CD3 positivity had sensitivity of 21%, specificity of 87%, positive predictive value of 45% and negative predictive value of 68% for diagnosis of AR. Discussion - These results demonstrate insufficient both sensitivity and specificity of urine immunocytology for CD3 for establishing diagnosis of renal AR. With respect to sensitivity our results are at odd with some of the previously published studies. Reasons for that are unclear, but may reflect either poor intrinsic performance of urine immunocytology for detection of AR, or may involve several technical factors like small initial volume of urine for analysis. Conclusion - Kidney biopsy still remains gold standard for detection AR. Urine immunocytology may have potential to become one of the methods for detection AR in kidney transplant patients, if sensitivity and specificity could be improved.
Vrsta sudjelovanja: Pozvano
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 198-1980955-0953, 108-1081873-1893
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Upisao u CROSBI: ikardum@kb-merkur.hr (ikardum@kb-merkur.hr), 5. Tra. 2010. u 17:15 sati



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