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Pregled bibliografske jedinice broj: 464943

Časopis

Autori: Mihovilović, Karlo; Kardum-Skelin, Ika; Ljubanović, Danica; Sabljar-Matovinović, Mirjana; Vidas, Željko; Knotek, Mladen
Naslov: Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: a Single Center Experience
( Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: a Single Center Experience )
Izvornik: Collegium Antropologicum (0350-6134) 34 (2010), 1; 63-67
Vrsta rada: članak
Ključne riječi: renal transplantation; acute rejection; immunocytology; urinary sediment
( renal transplantation; acute rejection; immunocytology; urinary sediment )
Sažetak:
Renal biopsy is a gold standard for establishing diagnosis of acute rejection of the renal allograft. However, being in- vasive, renal biopsy has potential significant complications and contraindications. Therefore, possibility to noninva- sively diagnose acute rejection would improve follow-up of kidney transplant patients. The purpose of this study was to evaluate urine immunocytology for T cells as a method for noninvasive identification of patients with acute renal allo- graft rejection in comparison to renal biopsy. In this prospective study a cohort of 56 kidney, or kidney-pancreas trans- plant recipients was included. Patients either received their transplant at the University Hospital »Merkur«, or have been followed at the »Merkur« Hospital. Patients were subject to either protocol or indication kidney biopsy (a total of 70 biop- sies), with simultaneous urine immunocytology (determination of CD3-positive cells in the urine sediment). Acute rejec- tion was diagnosed in 24 biopsies. 23 episodes were T-cell mediated (6 grade IA, 5 grade IB, 1 grade IIA, 1 grade III and 10 borderline), while in 1 case acute humoral rejection was diagnosed. 46 biopsies did not demonstrate acute rejection. CD3-positive cells were found in 21% of cases with acute rejection and in 13% of cases without rejection (n.s.). A finding of CD3-positive cells in urine had a sensitivity of 21% and specificity of 87% for acute rejection (including borderline), with positive predictive value of 45% and negative predictive value of 68%. Although tubulitis is a hallmark of acute T cell-mediated rejection, detection of T cells in urine sediment was insufficiently sensitive and insufficiently specific for diagnosing acute rejection in our cohort of kidney transplant recipients.
Projekt / tema: 198-0000000-3355, 044-0000000-3356, 108-1081873-1893, 198-1980955-0953
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Social Science Citation Index (SSCI) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Biologija,Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.collantropol.hr
URL cjelovitog teksta:
Google Scholar: Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: a Single Center Experience
Upisao u CROSBI: mknotek@mef.hr (mknotek@mef.hr), 7. Tra. 2010. u 18:17 sati



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