Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: a Single Center Experience (CROSBI ID 162981)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mihovilović, Karlo ; Kardum-Skelin, Ika ; Ljubanović, Danica ; Sabljar-Matovinović, Mirjana ; Vidas, Željko ; Knotek, Mladen Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: a Single Center Experience // Collegium antropologicum, 34 (2010), 1; 63-67

Podaci o odgovornosti

Mihovilović, Karlo ; Kardum-Skelin, Ika ; Ljubanović, Danica ; Sabljar-Matovinović, Mirjana ; Vidas, Željko ; Knotek, Mladen

engleski

Urine Immunocytology as a Noninvasive Diagnostic Tool for Acute Kidney Rejection: a Single Center Experience

Renal biopsy is a gold standard for establishing diagnosis of acute rejection of the renal allograft. However, being in- vasive, renal biopsy has potential significant complications and contraindications. Therefore, possibility to noninva- sively diagnose acute rejection would improve follow-up of kidney transplant patients. The purpose of this study was to evaluate urine immunocytology for T cells as a method for noninvasive identification of patients with acute renal allo- graft rejection in comparison to renal biopsy. In this prospective study a cohort of 56 kidney, or kidney-pancreas trans- plant recipients was included. Patients either received their transplant at the University Hospital »Merkur«, or have been followed at the »Merkur« Hospital. Patients were subject to either protocol or indication kidney biopsy (a total of 70 biop- sies), with simultaneous urine immunocytology (determination of CD3-positive cells in the urine sediment). Acute rejec- tion was diagnosed in 24 biopsies. 23 episodes were T-cell mediated (6 grade IA, 5 grade IB, 1 grade IIA, 1 grade III and 10 borderline), while in 1 case acute humoral rejection was diagnosed. 46 biopsies did not demonstrate acute rejection. CD3-positive cells were found in 21% of cases with acute rejection and in 13% of cases without rejection (n.s.). A finding of CD3-positive cells in urine had a sensitivity of 21% and specificity of 87% for acute rejection (including borderline), with positive predictive value of 45% and negative predictive value of 68%. Although tubulitis is a hallmark of acute T cell-mediated rejection, detection of T cells in urine sediment was insufficiently sensitive and insufficiently specific for diagnosing acute rejection in our cohort of kidney transplant recipients.

renal transplantation; acute rejection; immunocytology; urinary sediment

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

34 (1)

2010.

63-67

objavljeno

0350-6134

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija

Indeksiranost