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Pregled bibliografske jedinice broj: 472016

Časopis

Autori: Jaganjac, Morana
Naslov: Possible involvement of granulocyte oxidative burst in Nrf2 signaling in cancer
Izvornik: Indian journal of medical research (0971-5916) 131 (2010); 609-616
Vrsta rada: pregledni rad
Ključne riječi: granulocytes; oxidative stress; reactive oxygen species; Nrf2; cancer
Sažetak:
The activation process of granulocytes is accompanied by the intense production of reactive oxygen species (ROS). Overproduction of ROS is cytotoxic, damages macromolecules and can lead to the occurrence of lipid peroxidation. Cellular defense against the toxicity of ROS is enhancement of detoxifying enzymes activation. Regulation of many detoxifying enzymes is mediated by the antioxidant response element (ARE) that is located in the promoter region of related genes. In eukaryotes, there are only few transcription factors known to be activated by ROS. One of them is NF-E2-related factor 2 (Nrf2). Normally, Nrf2 is present in the cytoplasm as an inactive Keap1-Nrf2 complex. However, after direct attack by ROS, Nrf2 is released from Keap1 repression and translocated into nucleus where it binds ARE sequence to initiate gene expression. ROS may also influence nuclear factor-κB (NF-κB) intracellular signaling repressing the Nrf2-ARE pathway at transcriptional level. Since ROS are crucial in granulocyte-mediated tumor cell lysis the induction of NF-κB signaling pathway may be an important mechanism in suppressing the tumor growth.
Projekt / tema: 098-0982464-2519
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://icmr.nic.in/ijmr/2010/May/5.pdf
URL cjelovitog teksta:
Google Scholar: Possible involvement of granulocyte oxidative burst in Nrf2 signaling in cancer
Upisao u CROSBI: mzivkovi@irb.hr (mzivkovi@irb.hr), 28. Svi. 2010. u 09:31 sati



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