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Pregled bibliografske jedinice broj: 473654

Zbornik radova

Autori: Furčić, Ivana; Židovec-Lepej, Snježana; Mas, Antonio; Sáiz, Juan Carlos; Vince, Adriana; Nagy, Biserka
Naslov: Molecular characterization of Hepatitis C virus (HCV) strains in Croatia
( Molecular characterization of Hepatitis C virus (HCV) strains in Croatia )
Izvornik:
Skup: 15th International Symposium on Hepatitis C Virus and Related Viruses
Mjesto i datum: San Antonio, Texas, USA, October 5–9, 2008
Ključne riječi: Hepatitis C virus; NS5B; HCV genotype and subtype
( Hepatitis C virus; NS5B; HCV genotype and subtype )
Sažetak:
In Croatia, a limited number of studies described epidemiological data on HCV infection, overall prevalence, genotype distribution, route of infection ; and none of them included detailed molecular characterization of HCV genotypes and strains. The recent retrospective Croatian epidemiologic study (Vince et.al., 2006) confirmed, in a group of 1163 patients with chronic hepatitis C (anti-HCV positive with detectable HCV RNA in plasma), the overall prevalence of HCV subtypes 1b, 3a and 1a which is in concordance with data for the geographic region of southern and eastern European countries. Based on the data and using samples from the mentioned study (400 samples available), by amplifying and sequencing the NS5B and 5’NC regions we will try to confirm and determine more accurately HCV genotypes and subtypes, and further on perform genetic diversity and phylogenetic analysis of HCV in Croatia. We will establish in-house-methods for more accurate determination of HCV genotypes and subtypes, and molecular characterization of HCV, with ensured sensibility and repeatability. Established methods will be implemented in diagnostic centers in Croatia as standard methods for routine more accurate detection of HCV genotypes and subtypes, as it was done in other countries. We will present preliminary results of the first HCV molecular study conducted in Croatia.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: ifurcic@biolpmf.hr (ifurcic@biolpmf.hr), 14. Lip. 2010. u 16:34 sati



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