Postoperative abdominal and shoulder pain are two most common complications seen after laparoscopic cholecystectomy. Intraperitoneal (IP) administration of some drugs can be effective for relief of pain after laparoscopic surgery. The purpose of this study was to asses the effects of intraperitoneal application of plain bupivacaine or in combination with tramadol on pain after laparoscopic cholecystectomy. At the end of laparoscopic cholecystectomy 30 patients in each group received 50 ml saline 0.9% (group C), bupivacaine 0.25% (group B) or bupivacaine with tramadol (group T). VAS pain was estimated at 30 minutes, 1, 2, 4 and 24 hours after surgery. Postoperative analgesic requires were also assessed. Pain scores were significantly lower in group receiving the IP bupivacaine with tramadol and bupivacaine. Intraperitoneal applications of these drugs reduced consumption of supplementary postoperative analgesic medication. Intraperitoneal administration of bupivacaine with tramadol and bupivacaine are simple to use and effective in a reduction of pain after laparoscopic cholecystectomy.

Kliničke medicinske znanosti