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Pregled bibliografske jedinice broj: 480986

Zbornik radova

Autori: Wittine, Karlo; Stipković Babić, Maja; Kraljević Pavelić Sandra; Pavelić Krešimir; Mintas Mladen
Naslov: Sinteza i ispitivanje citostatskih djelovanja pirimidinskih i purinskih derivata L-askorbinske kiseline
Izvornik: Drugs of the Future / J. Prous, Jr. (ur.). - Barcelona : Thomson Reuters , 2010. PC.320.
ISSN: 0377-8282
Skup: EFMC-ISMC 2010 XXIst INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY
Mjesto i datum: Brussels, Belgija, 05-09.09.2010.
Ključne riječi: pirimidinske baze; L-askorbinska kiselina; citostatska ispitivanja
Sažetak:
Nucleoside analogues represent a valuble source that contributes significantly to the arsenal of chemotherapeutic agents against viruses and cancer. The principal aim of this study was to synthesize the new nucleoside congeners in which the sugar ring was substituted with L-ascorbic acid moiety and to evaluate their cytostatic activity potency. L-ascorbic acid itself has been found to be cytotoxic to some human tumor cells, neuroblastoma1, osteosarcoma and retinoblastoma.2 Ascorbic acid and ascorbyl esters have been found to inhibit the proliferation of mouse glioma and human brain tumor cells, glioma (U-373) and glioblastoma (T98G) cells and renal carcinoma cells.3, 4 In addition to that we have demonstrated that pyrimidine and purine derivatives of L-ascorbic acid exert cytostatic activity against malignant cell lines, especially leukemia (IC50 = 0.9 M) and murine mammary carcinoma (IC50 = 1.4 M), as well as other malignant tumor cell lines.5 Based on this finding we have synthesized a series of pyrimidine (1-12) and purine (13-15) derivatives of L-ascorbic acid containing the free hydroxy group (7-9) at C-5 of ethylenic spacer or amino group at C-4 position (5, 6, 10-15) of the lactone ring and evaluated their cytostatic potential.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 125-0982464-2922
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kemija
Upisao u CROSBI: mmintas@fkit.hr (mmintas@fkit.hr), 10. Ruj. 2010. u 12:59 sati



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