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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 488718

Časopis

Autori: Leović, Dinko; Sabol, Maja; Ozretić, Petar; Musani, Vesna; Car, Diana; Marjanović, Ksenija; Zubčić, Vedran; Sabol, Ivan; Sikora, Miroslav; Grce, Magdalena; Glavaš-Obrovac, Ljubica; Levanat, Sonja
Naslov: Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma
( Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma )
Izvornik: Head and neck (1043-3074) 34 (2012), 1; 104-112
Vrsta rada: članak
Ključne riječi: Hedgehog-Gli signaling; oral cancer; survivin; squamous cell carcinoma
( Hedgehog-Gli signaling; oral cancer; survivin; squamous cell carcinoma )
Sažetak:
The aim of this study was to examine the role of Hh-Gli signaling in oral and oropharyngeal squamous cell carcinoma (SCC). The role of this signaling pathway in SCC formation has not yet been elucidated. Sixty-four tissue and blood samples were collected from 60 SCC patients, all tobacco and alcohol users. Additional 6 buccal mucosa tissue samples were collected from non-smokers and non-drinkers as control tissue. Hedgehog-Gli pathway components were associated with clinical and pathological features. Broders' grade and N stage were associated with higher Ptch1 and lower Gli1 expression. Tumor stage was negatively associated with Smo expression, and tumor size was positively associated with p16 expression. Ptch1 and Shh were frequently detected in the surrounding stroma. Ptch1 was found to be correlated with p16 expression, as well as with survivin expression. The signaling pathway is activated in SCC and inducible in vitro by Shh protein.
Projekt / tema: 098-0982464-2510, 098-0982464-2461, 219-0982914-2176, 108-1080057-0043
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1002/hed.21696/abstract
Broj citata:
Altmetric:
DOI: 10.1002/hed.21696
URL cjelovitog teksta:
Google Scholar: Hh-Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma
Upisao u CROSBI: mcretnik@irb.hr (mcretnik@irb.hr), 28. Lis. 2010. u 16:13 sati



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