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Pregled bibliografske jedinice broj: 489307

Časopis

Autori: Cindrić, Marina; Čipak, Ana; Serly, Julianna; Plotniece, Aiva; Jaganjac, Morana; Mrakovčić, Lidija; Lovaković, Tomislava; Dedić, Azra; Soldo, Ivo; Duburs, Gunars; Žarković, Neven; Molnár, József
Naslov: Reversal of Multidrug Resistance in Murine Lymphoma Cells by Amphiphilic Dihydropyridine Antioxidant Derivative
Izvornik: Anticancer research (0250-7005) 30 (2010), 10; 4063-4070
Vrsta rada: članak
Ključne riječi: cancer; doxorubicin; MDR reversal; dihydropyridine derivative; oxidative stress; antioxidant
Sažetak:
Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies. The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance. The effects of amphiphilic dihydropyridine derivative K-2-11 were tested on MDR1-expressing mouse lymphoma cells and their parental control. The effects of K-2-11 with and without doxorubicin were studied by determination of cell viability, cell proliferation and production of reactive oxygen species. K-2-11 caused complete reversal of multidrug resistance of the MDR cells, being much more efficient than the positive control verapamil. Accordingly, the cytotoxic effects of doxorubicin were enhanced by K-2-11, both in the MDR and in parental cell line, while K-2-11 alone did not affect cell viability. K-2-11 also acted as an antioxidant, reducing the cellular generation of reactive oxygen species. Our results indicate the high potential of K-2-11 as a novel antioxidant with potent MDR-blocking ability that should be studied further for development in adjuvant anticancer treatments.
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://ar.iiarjournals.org/content/30/10/4071.abstract
URL cjelovitog teksta:
Google Scholar: Reversal of Multidrug Resistance in Murine Lymphoma Cells by Amphiphilic Dihydropyridine Antioxidant Derivative
Upisao u CROSBI: mstroser@mef.hr (mstroser@mef.hr), 2. Stu. 2010. u 14:40 sati



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