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Pregled bibliografske jedinice broj: 489319

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Autori: Čipak, Ana; Hasslacher, Meinhard; Andrišić, Luka; Jaganjac, Morana; Collinson, Emma J.; Tehlivets, Oksana; Dawes, Ian W.; Kohlwein, Sepp D.; Žarković, Neven
Naslov: Adaptation to oxidative stress mediated by catalase in D12 desaturase expressing yeast
Izvornik:
Skup: HNE-meeting : Lipid Oxidation, Human Diseases, and Aging
Mjesto i datum: Torino, Italija, 16.-18.06.2010.
Ključne riječi: oxidative stress; desaturase; yeast; catalase
Sažetak:
It is known that oxidative stress plays important role in various diseases among which is cancer. Disturbed antioxidative defence and reaction patterns to exogenous oxidative stress in tumors are often the reason for failure of therapy. Yeast functionally expressing D12 desaturase provides good model for the research of these processes. Analysis of expression profile by microarray, and experiments on different mutant strains, with or without functional expression of desaturase, together with activity of certain antioxidative enzymes provided answers to some questions about processes that take part in adaptation processes to oxidative stress caused by change in fatty acid content of cell membrane. During adaptation there are changes in lipid metabolism hand in hand with increase in catalase activity. Especially of interest is the fact that peroxisomal catalase is the one responsible to adaptation. Novel insight of the changes caused by changes in fatty acid content in cell membrane open new possibilities in target genes and proteins in cancer therapy.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Nema recenziju
Projekt / tema: 098-0982464-2519, 108-0000000-0028
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: lmrakov@irb.hr (lmrakov@irb.hr), 2. Stu. 2010. u 15:16 sati



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