engleski

Novel in vitro bone regeneration model comprises bioglass, 4-hydroxynonenal and/or protein

Bone healing is a complex biological process that could be prolonged or incomplete, especially concerning long bones and large joints defects, and often in elderly people or in polytraumatized patients. Various attempts are done to solve this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive due to its osteoconductive and osteostimulative properties. Since lipid peroxidation was defined as important parameter of systematic stress response in patients with traumatic brain injuries and bone fractures, 4-hydroxynonenal (HNE), as its final product and the major bioactive marker, represents particularly interesting biomolecule. HNE regulates differentiation, proliferation and apoptosis of cells and might therefore play important role regulating regeneration of damaged tissue such as bone. We investigated the concept of using bioactive glass coated with HNE and/or protein. Our results show stimulatory effect of HNE on cell growth and differentiation.

bone regeneration; HNE; bioglass

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