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Pregled bibliografske jedinice broj: 489832

Časopis

Autori: Hranjec, Marijana; Starčević, Kristina; Kraljević Pavelić, Sandra; Lučin, Pero; Pavelić, Krešimir; Karminski-Zamola, Grace
Naslov: Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles
Izvornik: European journal of medicinal chemistry (0223-5234) 46 (2011), 6; 2274-2279
Vrsta rada: članak
Ključne riječi: benzimidazoles; Schiff bases; antiproliferaive evaluation; UV/Vis and fluorescence spectroscopy
Sažetak:
A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by 1H and 13C NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.
Projekt / tema: 335-0000000-3532, 335-0982464-2393, 125-0982464-1356, 062-0620238-0223
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0223523411002108
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VKY-52BWVPT-6-1&_cdi=6135&_user=3875467&_pii=S0223523411002108&_origin=browse&_coverDate=06%2F30%2F2011&_sk=999539993&view=c&wchp=dGLzVlb-zSkWl&md5=c617e372608fa062014ca8b9da7e0a54&ie=/sdarticle.pdf
Broj citata:
Altmetric:
DOI: 10.1016/j.ejmech.2011.03.008
URL cjelovitog teksta:
Google Scholar: Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles
Upisao u CROSBI: mhranjec@fkit.hr (mhranjec@fkit.hr), 4. Stu. 2010. u 16:29 sati



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