Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles (CROSBI ID 167006)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hranjec, Marijana ; Starčević, Kristina ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Pavelić, Krešimir ; Karminski-Zamola, Grace Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles // European journal of medicinal chemistry, 46 (2011), 6; 2274-2279. doi: 10.1016/j.ejmech.2011.03.008

Podaci o odgovornosti

Hranjec, Marijana ; Starčević, Kristina ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Pavelić, Krešimir ; Karminski-Zamola, Grace

engleski

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by 1H and 13C NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.

benzimidazoles ; Schiff bases ; antiproliferaive evaluation ; UV/Vis and fluorescence spectroscopy

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

46 (6)

2011.

2274-2279

objavljeno

0223-5234

1768-3254

10.1016/j.ejmech.2011.03.008

Povezanost rada

Kemija, Temeljne medicinske znanosti

Poveznice
Indeksiranost