Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles (CROSBI ID 167006)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Hranjec, Marijana ; Starčević, Kristina ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Pavelić, Krešimir ; Karminski-Zamola, Grace
engleski
Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles
A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by 1H and 13C NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.
benzimidazoles ; Schiff bases ; antiproliferaive evaluation ; UV/Vis and fluorescence spectroscopy
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Podaci o izdanju
46 (6)
2011.
2274-2279
objavljeno
0223-5234
1768-3254
10.1016/j.ejmech.2011.03.008
Povezanost rada
Kemija, Temeljne medicinske znanosti