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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 492733

Časopis

Autori: Dragojević, Snježana; Šunjić, Vitomir; Bencetić-Mihaljević, Vlatka; Ralić, Jovica; Mesić, Milan; Jivkov Elenkov, Ivaylo; Filipović Sučić, Anita; Čempuh klonkay, Andreja; Lerman, Lidija; Ilijaš, Marina; Gabelica-Marković, Vesna; Malnar, Ivica
Naslov: Determination of aqueous stability and degradation products of series of coumarin dimers
( Determination of aqueous stability and degradation products of series of coumarin dimers )
Izvornik: Journal of pharmaceutical and biomedical analysis (0731-7085) 54 (2011), 1; 37-47
Vrsta rada: članak
Ključne riječi: aqueous stability; coumarin dimers; HPLC-DAD-MS analysis; decomposition rate; metabolic stablity
( aqueous stability; coumarin dimers; HPLC-DAD-MS analysis; decomposition rate; metabolic stablity )
Sažetak:
The stability in aqueous solution of five classes of coumarin dimers (I–V, compounds 1–29) was studied by HPLC–MS/MS at various pH values. The relationship between chemical structure and stability is discussed. It was found that dimeric compounds with strong electron withdrawing groups (EWGs) on the alfa-carbon to the bridging C-atom are stable at all pH values, whereas other derivatives undergo retro-Michael addition at rates which are also affected by the substituents on the aromatic rings. In some casesformation of stable isomers or oxidation products was observed. In order to evaluate their developability and potential for progression to in vivo studies, representative compounds were tested in an in vitro microsomal stability assay.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija
URL Internet adrese: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TGX-50S8PKN-4-11&_cdi=5266&_user=3875467&_pii=S0731708510004619&_origin=browse&_coverDate=01%2F05%2F2011&_sk=999459998&view=c&wchp=dGLbVzW-zSkzS&md5=c4f4aff8a8b633237770446472d835c6&ie=/sdarticle.pdf
http://www.sciencedirect.com/science/article/pii/S0731708510004619
Broj citata:
Altmetric:
DOI: 10.1016/j.jpba.2010.08.002
URL cjelovitog teksta:
Google Scholar: Determination of aqueous stability and degradation products of series of coumarin dimers
Upisao u CROSBI: vgabelica@gsk-icz.hr (vgabelica@gsk-icz.hr), 26. Stu. 2010. u 14:22 sati



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