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Pregled bibliografske jedinice broj: 498329

Časopis

Autori: Wittine, Karlo; Benci, Krešimir; Kraljević Pavelić, Sandra; Pavelić, Krešimir; Bratulić, Siniša; Hock, Karlo; Balzarini, Jan; Mintas, Mladen
Naslov: Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety
Izvornik: Medicinal chemistry research (1054-2523) 20 (2011), 3; 280-287
Vrsta rada: članak
Ključne riječi: acyclic nucleoside analogues; purine and pyrimidine derivatives; cytostatic activity; antiviral activity
Sažetak:
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in which the sugar moiety was replaced by a sterically constrained Z-4-amino-, 4-aminohydrochloride-2-butenyl, or aliphatic 4-aminohydrochloride-2-butyl moiety were synthesized and evaluated for their antiviral and cytostatic activity potency. Cytostatic evaluation of the novel compounds on selected panel of human tumour cell lines showed that the majority of compounds exerted a non-specific antiproliferative effect at the highest tested concentration (i.e. 1 x 10-4 M) against all cell lines. Nevertheless, a rather moderate but selective antiproliferative effects on HeLa cell cultures in comparison to normal fibroblasts WI 38, was observed for compounds 15 and 21. No antiviral activity was observed, except for compounds 3, 4 and 5 that showed anti-HIV activity at 50% effective concentration ranging between 29 and 96 µM.
Projekt / tema: 335-0982464-2393, 335-0000000-3532
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Temeljne medicinske znanosti
URL Internet adrese: http://www.springerlink.com/content/f618p055488u7227/
Broj citata:
Altmetric:
DOI: 10.1007/s00044-010-9318-1
URL cjelovitog teksta:
Google Scholar: Synthesis, cytostatic and anti-viral activity evaluation of the novel acyclic nucleoside analogues containing a sterically constrained (Z)-4-amino-2-butenyl moiety
Upisao u CROSBI: pavelic@uniri.hr (pavelic@uniri.hr), 15. Sij. 2011. u 15:52 sati



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