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Pregled bibliografske jedinice broj: 502040

Časopis

Autori: Kraljević Pavelić, Sandra; Sedić, Mirela; Bošnjak, Hrvojka; Spaventi, Šime; Pavelić, Krešimir
Naslov: Metastasis : new perspectives on an old problem
Izvornik: Molecular cancer (1476-4598) 10 (2011); 23-36
Vrsta rada: pregledni rad
Ključne riječi: metastasis ; organ tropism ; cancer stem cells ; proteomics
Sažetak:
Many hypotheses have been postulated to explain the intricate nature of the metastatic process, but none of them completely accounted for the actual biological and clinical observations. Consequently, metastasis still remains an open issue with only few metastasis-inducing proteins experimentally validated so far. Recently proposed novel metastatic model, where serial and parallel metastatic processes are adequately integrated, might help to bridge the current gap between experimental results and clinical observations. In addition, the identification, isolation and molecular characterization of cancer stem cells, a population of the cells within the tumour mass able to proliferate, self-renew and induce tumorigenesis, will shed new light on the complex molecular events mediating metastasis, invasion and resistance to therapy. Understanding the molecular basis of these tumour characteristics will usher in a new age of individualized cancer therapy. In this review article, we will provide a current overview of molecular mechanisms underpinning metastasis, and discuss recent findings in this field obtained by global molecular profiling strategies such as proteomics.
Projekt / tema: 335-0000000-3532, 335-0982464-2393, 101-0982464-2277
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.molecular-cancer.com/content/pdf/1476-4598-10-22.pdf
http://www.molecular-cancer.com/content/10/1/22/abstract
Broj citata:
Altmetric:
DOI: 10.1186/1476-4598-10-22
URL cjelovitog teksta:
Google Scholar: Metastasis : new perspectives on an old problem
Upisao u CROSBI: sandrakp@uniri.hr (sandrakp@uniri.hr), 11. Vel. 2011. u 16:33 sati



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