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Pregled bibliografske jedinice broj: 50339

Zbornik radova

Autori: Nagy, Biserka; Furčić, Ivana
Naslov: DNA topoisomerase I and repair of genomic damage
( DNA topoisomerase I and repair of genomic damage )
Izvornik: Current Studies of Biotechnology / Zlatko, Kniewald i ost. (ur.). - Zagreb : Hrvatsko biotehnološko društvo , 2000. 15-18.
Skup: Biotechnology and Biomedicine with international participation
Mjesto i datum: Zagreb, Hrvatska, 22-23.02.1999.
Ključne riječi: Xeroderma pigmentosum cells; topoisomerase I activity; DNA damage
( Xeroderma pigmentosum cells; topoisomerase I activity; DNA damage )
Sažetak:
Recent evidence indicates that unrepaired genomic damage influences the catalytic activities of DNA topoisomerases. DNA lesions such as base mismatches, pyrimidinic dimers, 6, 4-photoproducts, apurinic and apyrimidinic sites and others, enhance topoisomerase I mediated DNA cleavage. These findings suggest that topoisomerase activity can be influenced by spontaneous, as well as environmentally induced damages to DNA. In this study the catalytic activity of topoisomerase I was examined Xeroderma pigmentosum cell lines B and C and compared with the activity of normal human cells. The data show that topoisomerase I levels are higher in two repair-deficient cell lines. This provide novel insight into the mechanism of action of topoisomerases and raise new questions regarding mechanism of topoisomerase-targeting drugs.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Cjeloviti rad (više od 1500 riječi)
Vrsta recenzije: Domaća recenzija
Projekt / tema: 119118
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Biologija



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