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Pregled bibliografske jedinice broj: 50397

Zbornik radova

Autori: Ljubičić, Neven; Banić, Marko; Kujundžic, Milan; Antic, Zoran; Vrkljan, Milan; Kovacevic, Igor; Hrabar, Davor;
Naslov: The effect of eradicating Helicobacter Pylori infection on the course of hyperplastic gastric polyps
( The effect of eradicating Helicobacter Pylori infection on the course of hyperplastic gastric polyps )
Izvornik: Gut 1999;45(Suppl V) / Farthing, J, G, Michael ; (ur.). - London : British Medicaj Journal , 1999. A41.
Skup: 7th United European Gastroenterology Week
Mjesto i datum: Rim, Italija, 25-30.11.1999
Ključne riječi: Helicobacter pylori; Hiperplastični želučani polipi; Eradikacijska terapija
( Helicobacter pylori; Hyperplastic gastric polyps; Eradication therapy )
Sažetak:
Background: Histopathological and clinical data suggest that H. Pylori is the cause of chronic gastritis and peptic ulcer disease. However, little has been written about the potential causal relation of H. Pylori infection to hyperplastic gastric polyps. Aims: The aim of this study was to determine the effect of eradicating H. Pylori infection on the course on hyperplastic gastric polyps. Methods: Twenty-one patients with histologically proven gastric hyperplastic polyps were included in a study. Among them, 16 patients (76%) were H. Pylori positive, as assessed by histology and CLO-test. The treatment of H. Pylori infection consisted of a 2-week course of omeprazole or pantoprazole and a one-week course of metronidazole and amoxicillin or clarithromycin and amoxicillin. Control endoscopy was performed at least four weeks after treating the H. Pylori infection, and then, every 3 to 4 months. After the treatment of H. Pylori infection the median follow-up was 12 months (range, 3 to 16 months). Results: H. Pylori was completely eradicated in all patients. Disappearance or almost total regression of the hyperplastic gastric polyps was observed in 7 of the 16 H. Pylori positive patients (44%, 95%CI 19% to 68%). However, complete disappearance was evident in only 2 of the 7 patients at the first endoscopy after the treatment of H. Pylori infection. The endoscopic snare polypectomy was done in nine patients in whom disappearance or almost total regression of the gastric polyp was not observed after H. Pylori eradication, as well as in five patients with hyperplastic gastric polyps who were negative for H. Pylori. During the follow-up period no gastric polyp recurrence was observed. Conclusions: Our results suggest that the cure of H. Pylori infection associated with hyperplastic gastric polyps resulted in complete polyp regression in more than 40% of patients. Therefore, for patients with hyperplastic gastric polyps and concurrent H. Pylori infection an antibiotic treatment designed to eradicate H. Pylori appears to be recommended before further therapeutic options are considered.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 108104
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Javno zdravstvo i zdravstvena zaštita



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